补充益生菌对成人 2 型糖尿病患者血糖谱的影响：随机对照试验的分级评估系统综述和剂量反应荟萃分析。

IF 2.9 Q3 NUTRITION & DIETETICS

Clinical nutrition ESPEN Pub Date : 2024-09-28 DOI:10.1016/j.clnesp.2024.09.014

Najmeh Hejazi , Hamid Ghalandari , Raha Rahmanian , Fatemeh Haghpanah , Maede Makhtoomi , Amirhossein Asadi , Moein Askarpour

{"title":"补充益生菌对成人 2 型糖尿病患者血糖谱的影响：随机对照试验的分级评估系统综述和剂量反应荟萃分析。","authors":"Najmeh Hejazi , Hamid Ghalandari , Raha Rahmanian , Fatemeh Haghpanah , Maede Makhtoomi , Amirhossein Asadi , Moein Askarpour","doi":"10.1016/j.clnesp.2024.09.014","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>Disturbed glycemia and the resulting type 2 diabetes (T2D) are significant health concerns. Various approaches have been examined to improve glycemic control in patients with T2D. Modification of gut microbiome via administering probiotics has been extensively studied. The present study aims to sum up the existing literature which investigated the effect of probiotics on glycemic indices in individuals with T2D in the format of randomized controlled trials (RCTs).</div></div><div><h3>Methods</h3><div>Online medical databases (PubMed, Scopus, and Web of Science) were searched from inception to January 2024. Eligible studies were included using pre-defined inclusion and exclusion criteria. Outcome variables included fasting blood sugar (FBS), insulin, hemoglobin A1c (HbA1c), and homeostatic model of insulin resistance (HOMA-IR). Weighted mean differences (WMDs) were estimated. Subgroup and dose-response analyses were conducted. P-values <0.05 were considered as statistically significant.</div></div><div><h3>Results</h3><div>Out of 5636 records retrieved by the initial search, thirty-two RCTs were included in the final analyses. Supplementation with probiotics was observed to significantly improve indices of glycemic control; including FBS (WMD: −13.27 mg/dl; 95 % CI: −18.31, −8.22), HbA1c (WMD: −0.44 %; 95 % CI: −0.59, −0.28), insulin (WMD: −1.33 μIU/ml; 95 % CI: −2.57, −0.08), and HOMA-IR (WMD: −0.95; 95 % CI: −1.71, −0.18). Dose-response analysis revealed that increased duration of intervention results in a larger reduction only in FBS.</div></div><div><h3>Conclusion</h3><div>Supplementation with probiotics seems to improve indices of glycemic control. Nonetheless, taken into account the notable heterogeneity (with regard to dosage, duration, and the species/strains used) between the included studies and low quality of evidence, caution must be considered, especially when long-term clinical implications are intended.</div></div>","PeriodicalId":10352,"journal":{"name":"Clinical nutrition ESPEN","volume":"64 ","pages":"Pages 133-143"},"PeriodicalIF":2.9000,"publicationDate":"2024-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Effects of probiotics supplementation on glycemic profile in adults with type 2 diabetes mellitus: A grade-assessed systematic review and dose–response meta-analysis of randomized controlled trials\",\"authors\":\"Najmeh Hejazi , Hamid Ghalandari , Raha Rahmanian , Fatemeh Haghpanah , Maede Makhtoomi , Amirhossein Asadi , Moein Askarpour\",\"doi\":\"10.1016/j.clnesp.2024.09.014\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><div>Disturbed glycemia and the resulting type 2 diabetes (T2D) are significant health concerns. Various approaches have been examined to improve glycemic control in patients with T2D. Modification of gut microbiome via administering probiotics has been extensively studied. The present study aims to sum up the existing literature which investigated the effect of probiotics on glycemic indices in individuals with T2D in the format of randomized controlled trials (RCTs).</div></div><div><h3>Methods</h3><div>Online medical databases (PubMed, Scopus, and Web of Science) were searched from inception to January 2024. Eligible studies were included using pre-defined inclusion and exclusion criteria. Outcome variables included fasting blood sugar (FBS), insulin, hemoglobin A1c (HbA1c), and homeostatic model of insulin resistance (HOMA-IR). Weighted mean differences (WMDs) were estimated. Subgroup and dose-response analyses were conducted. P-values <0.05 were considered as statistically significant.</div></div><div><h3>Results</h3><div>Out of 5636 records retrieved by the initial search, thirty-two RCTs were included in the final analyses. Supplementation with probiotics was observed to significantly improve indices of glycemic control; including FBS (WMD: −13.27 mg/dl; 95 % CI: −18.31, −8.22), HbA1c (WMD: −0.44 %; 95 % CI: −0.59, −0.28), insulin (WMD: −1.33 μIU/ml; 95 % CI: −2.57, −0.08), and HOMA-IR (WMD: −0.95; 95 % CI: −1.71, −0.18). Dose-response analysis revealed that increased duration of intervention results in a larger reduction only in FBS.</div></div><div><h3>Conclusion</h3><div>Supplementation with probiotics seems to improve indices of glycemic control. Nonetheless, taken into account the notable heterogeneity (with regard to dosage, duration, and the species/strains used) between the included studies and low quality of evidence, caution must be considered, especially when long-term clinical implications are intended.</div></div>\",\"PeriodicalId\":10352,\"journal\":{\"name\":\"Clinical nutrition ESPEN\",\"volume\":\"64 \",\"pages\":\"Pages 133-143\"},\"PeriodicalIF\":2.9000,\"publicationDate\":\"2024-09-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical nutrition ESPEN\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2405457724013184\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"NUTRITION & DIETETICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical nutrition ESPEN","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2405457724013184","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"NUTRITION & DIETETICS","Score":null,"Total":0}

引用次数: 0

摘要

背景：血糖紊乱和由此导致的 2 型糖尿病（T2D）是严重的健康问题。人们研究了各种方法来改善 T2D 患者的血糖控制。通过服用益生菌来改变肠道微生物群已得到广泛研究。本研究旨在总结现有文献，这些文献以随机对照试验（RCTs）的形式研究了益生菌对 T2D 患者血糖指数的影响：方法：检索了从开始到 2024 年 1 月的在线医学数据库（PubMed、Scopus 和 Web of Science）。采用预先定义的纳入和排除标准纳入符合条件的研究。结果变量包括空腹血糖（FBS）、胰岛素、血红蛋白A1c（HbA1c）和胰岛素抵抗稳态模型（HOMA-IR）。对加权平均差（WMD）进行了估算。进行了分组和剂量反应分析。P 值结果：在初步检索到的 5636 条记录中，有 32 项 RCT 纳入了最终分析。据观察，补充益生菌可显著改善血糖控制指标，包括 FBS（WMD：-13.27 mg/dl；95% CI：-18.31，-8.22）、HbA1c（WMD：-0.44 %；95% CI：-0.59，-0.28）、胰岛素（WMD：-1.33 μIU/ml；95% CI：-2.57，-0.08）和 HOMA-IR（WMD：-0.95；95% CI：-1.71，-0.18）。剂量-反应分析表明，干预时间的延长仅导致 FBS 下降幅度增大：结论：补充益生菌似乎能改善血糖控制指标。结论：补充益生菌似乎能改善血糖控制指标。然而，考虑到所纳入研究之间存在明显的异质性（剂量、持续时间和使用的种类/菌株）以及证据质量较低，必须谨慎考虑，尤其是在希望产生长期临床影响时。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Effects of probiotics supplementation on glycemic profile in adults with type 2 diabetes mellitus: A grade-assessed systematic review and dose–response meta-analysis of randomized controlled trials

Background

Disturbed glycemia and the resulting type 2 diabetes (T2D) are significant health concerns. Various approaches have been examined to improve glycemic control in patients with T2D. Modification of gut microbiome via administering probiotics has been extensively studied. The present study aims to sum up the existing literature which investigated the effect of probiotics on glycemic indices in individuals with T2D in the format of randomized controlled trials (RCTs).

Methods

Online medical databases (PubMed, Scopus, and Web of Science) were searched from inception to January 2024. Eligible studies were included using pre-defined inclusion and exclusion criteria. Outcome variables included fasting blood sugar (FBS), insulin, hemoglobin A1c (HbA1c), and homeostatic model of insulin resistance (HOMA-IR). Weighted mean differences (WMDs) were estimated. Subgroup and dose-response analyses were conducted. P-values <0.05 were considered as statistically significant.

Results

Out of 5636 records retrieved by the initial search, thirty-two RCTs were included in the final analyses. Supplementation with probiotics was observed to significantly improve indices of glycemic control; including FBS (WMD: −13.27 mg/dl; 95 % CI: −18.31, −8.22), HbA1c (WMD: −0.44 %; 95 % CI: −0.59, −0.28), insulin (WMD: −1.33 μIU/ml; 95 % CI: −2.57, −0.08), and HOMA-IR (WMD: −0.95; 95 % CI: −1.71, −0.18). Dose-response analysis revealed that increased duration of intervention results in a larger reduction only in FBS.

Conclusion

Supplementation with probiotics seems to improve indices of glycemic control. Nonetheless, taken into account the notable heterogeneity (with regard to dosage, duration, and the species/strains used) between the included studies and low quality of evidence, caution must be considered, especially when long-term clinical implications are intended.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Clinical nutrition ESPEN NUTRITION & DIETETICS-

CiteScore

4.90

自引率

3.30%

发文量

512

期刊介绍： Clinical Nutrition ESPEN is an electronic-only journal and is an official publication of the European Society for Clinical Nutrition and Metabolism (ESPEN). Nutrition and nutritional care have gained wide clinical and scientific interest during the past decades. The increasing knowledge of metabolic disturbances and nutritional assessment in chronic and acute diseases has stimulated rapid advances in design, development and clinical application of nutritional support. The aims of ESPEN are to encourage the rapid diffusion of knowledge and its application in the field of clinical nutrition and metabolism. Published bimonthly, Clinical Nutrition ESPEN focuses on publishing articles on the relationship between nutrition and disease in the setting of basic science and clinical practice. Clinical Nutrition ESPEN is available to all members of ESPEN and to all subscribers of Clinical Nutrition.