通过 Suzukii-Miyaura 交叉偶联生成新的三环芳基喹唑啉衍生物。

IF 2.5 4区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

ChemistryOpen Pub Date : 2024-09-27 DOI:10.1002/open.202400197

Burkhon Elmuradov, Rasul Okmanov, Bakhromjon Juraev, Gerald Dräger, Holger Butenschön

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引用次数: 0

摘要

报告了一些新的脱氧鸭嘴花碱酮（2,3-二氢吡咯并[2,1-b]喹唑啉-9(1H)-酮）和麦金唑啉酮（6,7,8,9-四氢-11H-吡啶并[2,1-b]喹唑啉-11-酮）衍生物，这些衍生物在 C7/C8 和 C5 处具有芳基取代基。这些化合物是同类化合物中罕见的代表，它们是以醋酸钯为催化剂，通过 7-溴-2,3-二氢[2,1-b]喹唑啉-9-(1H)-酮、5,7-二溴-2,3-二氢[2,1-b]喹唑啉-9-(1H)-酮或 8-溴ackinazolinone 与各自的芳硼酸之间的 Suzuki-Miyaura 交叉偶联反应高产制备的。对六种产物进行了光谱分析和 X 射线晶体结构分析。

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New Tricyclic Aryl Quinazoline Derivatives by Suzuki-Miyaura Cross-Coupling.

A number of new deoxyvasicinone (2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one) and mackinazolinone (6,7,8,9-tetrahydro-11H-pyrido[2,1-b]quinazolin-11-one) derivatives with aryl substituents at C7/C8 and at C5 are reported. These compounds are rare representatives of their kind and were prepared in high yields by Suzuki-Miyaura cross-coupling reactions between 7-bromo-2,3-dihydro[2,1-b]quinazoline-9-(1H)-one, 5,7-dibromo-2,3-dihydro[2,1-b]quinazoline-9-(1H)-one or 8-bromomackinazolinone and respective arylboronic acids with palladium acetate as the catalyst. The products were characterized spectroscopically and, in addition, by X-ray crystal structure analyses in six cases.

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来源期刊

ChemistryOpen CHEMISTRY, MULTIDISCIPLINARY-

CiteScore

4.80

自引率

4.30%

发文量

143

审稿时长

1 months

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