塞马鲁肽治疗与 2 型糖尿病患者冠状动脉炎症的关系:基于冠状动脉周围脂肪组织衰减的回顾性研究。

IF 8.5 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS
Yanhong Li, Wenjing Yao, Tianxing Wang, Qian Yang, Kexin Song, Feifei Zhang, Fan Wang, Yi Dang
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引用次数: 0

摘要

背景:冠状动脉周围脂肪衰减指数(FAI冠状动脉周围脂肪衰减指数(FAI)已成为反映冠状动脉炎症程度的一种新颖而敏感的生物标志物。塞马鲁肽已被证实具有独立于低血糖的心血管保护作用;然而,它对冠状动脉炎症的影响仍然难以捉摸。本研究旨在探讨基于FAI的2型糖尿病(T2DM)患者的塞马鲁肽治疗与冠状动脉炎症之间的关系:本研究纳入了在河北省总医院接受冠状动脉计算机断层扫描(CCTA)的497例T2DM患者,其中93例接受了塞马鲁肽治疗(Sema+),404例未接受治疗(Sema-)。研究人员收集了两组患者的临床数据、实验室指标和CCTA参数,并对两组患者的基线数据进行了比较。采用倾向评分匹配法(PSM)调整混杂因素,并比较冠状动脉周围FAI。采用多变量线性回归模型分析塞马鲁肽治疗与冠状动脉周围FAI之间的关系:结果:在PSM之前,接受过塞马鲁肽治疗的患者的LAD和LCX冠状动脉周围FAI低于未接受塞马鲁肽治疗的患者。PSM 分析结果显示,与 Sema 组相比,Sema + 组患者三条主要冠状动脉的 FAI 均较低。多变量线性回归分析显示,塞马鲁肽治疗与三大冠状动脉FAI降低之间存在独立关联。这种关联在不同类型的T2DM患者中存在差异:结论:塞马鲁肽治疗可能与 T2DM 患者冠状动脉炎症的降低有关,这可能是其心血管保护机制的部分原因。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Association of semaglutide treatment with coronary artery inflammation in type 2 diabetes mellitus patients: a retrospective study based on pericoronary adipose tissue attenuation.

Background: The pericoronary fat attenuation index (FAI) has emerged as a novel and sensitive biomarker reflecting the degree of coronary artery inflammation. Semaglutide has been demonstrated to exert a cardiovascular protective effect independent of hypoglycemia; however, its impact on coronary artery inflammation remains elusive. This study aimed to investigate the association between semaglutide treatment and coronary artery inflammation based on FAI in patients with type 2 diabetes mellitus (T2DM).

Methods: This study enrolled 497 T2DM patients who underwent coronary computed tomography angiography (CCTA) at Hebei General Hospital, of whom 93 treated with semaglutide (Sema+) and 404 did not (Sema-). Clinical data, laboratory indicators, and CCTA parameters were collected and compared between the two groups at baseline. Propensity score matching (PSM) was used to adjust for confounders, and pericoronary FAI was compared. Multivariate linear regression models were used to analyze the association between semaglutide treatment and pericoronary FAI.

Results: Before PSM, pericoronary FAI of the LAD and LCX was lower in patients treated with semaglutide than those without semaglutide treatment. The results of the PSM analysis revealed a lower FAI in all three major coronary arteries in the Sema + group compared to the Sema- group. Multivariate linear regression analyses revealed an independent association between semaglutide treatment and reduced FAI in all three major coronary arteries. This association varied across T2DM patients of differing profiles.

Conclusion: Semaglutide treatment may be associated with lower coronary artery inflammation in patients with T2DM, which might partially explain its cardiovascular protective mechanism.

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来源期刊
Cardiovascular Diabetology
Cardiovascular Diabetology 医学-内分泌学与代谢
CiteScore
12.30
自引率
15.10%
发文量
240
审稿时长
1 months
期刊介绍: Cardiovascular Diabetology is a journal that welcomes manuscripts exploring various aspects of the relationship between diabetes, cardiovascular health, and the metabolic syndrome. We invite submissions related to clinical studies, genetic investigations, experimental research, pharmacological studies, epidemiological analyses, and molecular biology research in this field.
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