通过动脉空气栓塞模拟有意识大鼠的脑缺血中风

IF 0.9 4区医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL

Bulletin of Experimental Biology and Medicine Pub Date : 2024-09-01 Epub Date: 2024-09-30 DOI:10.1007/s10517-024-06231-8

V A Palikov, N B Pavlov, R R Amirov, A M Ismailova, V A Kazakov, Yu A Palikova, I D Rubinsteyn, S O Afanasyeva, E S Mikhailov, S G Semushina, I A Dyachenko, A T Logunov, A N Murashev

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引用次数: 0

摘要

绝大多数脑缺血的病因是血管栓塞。在本研究中，我们研究了向有意识的大鼠颈内动脉注入大气气泡引起的栓塞。栓塞建模后，动物立即出现行为异常，24 小时后发现脑损伤灶。动物在栓塞后 5 天内死亡。与麻醉动物模型相比，所提出的清醒大鼠脑缺血实验模型更贴切，更符合实际情况，而且可以在模型制作后立即进行生理测试。

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Modeling of Cerebral Ischemic Stroke in Conscious Rats via Arterial Air Embolization.

The etiological factor of cerebral ischemia in the vast majority of cases is vascular embolism. In the present study we investigated embolism caused by atmospheric air bubbles injected into the internal carotid artery of conscious rats. Immediately after embolism modeling, behavioral abnormalities were observed in the animals, and after 24 h, foci of brain damage were detected. The death of animals was observed within 5 days after embolism. The proposed experimental model of cerebral ischemia in conscious rats is more relevant and better corresponds to real conditions than the model on narcotized animals and allows to perform physiological tests immediately after modeling.

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来源期刊

Bulletin of Experimental Biology and Medicine 医学-医学：研究与实验

CiteScore

1.50

自引率

14.30%

发文量

265

审稿时长

2 months

期刊介绍： Bulletin of Experimental Biology and Medicine presents original peer reviewed research papers and brief reports on priority new research results in physiology, biochemistry, biophysics, pharmacology, immunology, microbiology, genetics, oncology, etc. Novel trends in science are covered in new sections of the journal - Biogerontology and Human Ecology - that first appeared in 2005. World scientific interest in stem cells prompted inclusion into Bulletin of Experimental Biology and Medicine a quarterly scientific journal Cell Technologies in Biology and Medicine (a new Russian Academy of Medical Sciences publication since 2005). It publishes only original papers from the leading research institutions on molecular biology of stem and progenitor cells, stem cell as the basis of gene therapy, molecular language of cell-to-cell communication, cytokines, chemokines, growth and other factors, pilot projects on clinical use of stem and progenitor cells. The Russian Volume Year is published in English from April.