评估单心室生理学婴儿的生长和喂养耐受性，将接受回顾性标准护理喂养方案的婴儿与接受配方奶或纯母乳喂养方案的婴儿进行比较。

IF 0.9 4区医学 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS

Cardiology in the Young Pub Date : 2024-09-30 DOI:10.1017/S1047951124025617

Megan Horsley, Amiee Trauth, David S Cooper, Cynthia Blanco, Zhiqian Gao, Lindsey Justice

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引用次数: 0

摘要

目标：确定心脏手术后开始喂养 30 天后体重增长速度（克/天）和其他临床结果是否有所改善：与非协议 "标准护理 "相比，确定单心室生理学婴儿在心脏手术后开始喂养 30 天后的体重增加速度（克/天）和其他临床结果是否有所改善：这项回顾性队列研究比较了接受新生儿外科姑息治疗的单心室生理学足月婴儿。回顾性对照组（RCG）按照单一中心的非协议标准护理进行喂养，并与之前协议多站点随机对照试验中被分配到超高速胎儿监护组或对照组（TCG）的婴儿进行比较。主要结果是体重增长速度。次要结果包括体重 Z 值的变化、喂养不耐受和坏死性小肠结肠炎的发生率：与之前的试验患者（EHM = 55 例，TCG = 52 例）相比，我们评估了 45 例患有单心室生理学的手术姑息新生儿。两组的基线人口统计学特征相似，但 RCG 患有左心发育不全综合征的患者较少（51% vs. 77% vs. 84%，P = 0.0009）。RCG 组的生长速度与 TCG 组相似（7.5 克/天 vs. 8.2 克/天），两组的生长速度均明显低于 EHM 组（12 克/天）。RCG组与TCG组坏死性小肠结肠炎/疑似坏死性小肠结肠炎的发生率相似，但RCG组明显高于EHM组（20.5% vs. 3.6%，p = 0.033）。其他疾病的发生率相似：结论：单心室生理的新生儿在手术姑息后接受 EHM 饮食时，短期生长情况有所改善，坏死性小肠结肠炎或疑似坏死性小肠结肠炎的风险也有所降低。

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Evaluation of growth and feeding tolerance in infants with single-ventricle physiology receiving retrospective standard of care feeding regimens compared with protocolised formula or exclusive human milk feeding regimens.

Objective: Determine whether weight gain velocity (g/day) 30 days after initiating feeds following cardiac surgery and other clinical outcomes improve in infants with single-ventricle physiology fed an exclusive human milk (EHM) diet with early fortification compared to non-protocolised "standard of care."

Methods: This retrospective cohort study compares term infants with single-ventricle physiology who underwent neonatal surgical palliation. The retrospective control group (RCG) was fed according to non-protocolised standard of care at a single centre and was compared with infants in a previous protocolised multi-site randomised controlled trial assigned to either an EHM group or a control group (TCG). The primary outcome measure is weight gain velocity. Secondary outcomes include change in weight z-score, and incidence of feeding intolerance and necrotising enterocolitis.

Results: We evaluated 45 surgically palliated neonates with single-ventricle physiology compared to the prior trial patients (EHM = 55, TCG = 52). Baseline demographics were similar between groups, except the RCG had fewer patients with hypoplastic left heart syndrome (51% vs. 77% vs. 84%, p = 0.0009). The RCG grew similarly to the TCG (7.5 g/day vs. 8.2 g/day), and both groups had significantly lower growth than the EHM group (12 g/day). Necrotising enterocolitis/suspected necrotising enterocolitis were similar in the RCG versus TCG but significantly higher in the RCG compared to the EHM group (20.5% vs. 3.6%, p = 0.033). Incidences of other morbidities were similar.

Conclusions: Neonates with single-ventricle physiology have improved short-term growth and decreased risk of necrotising enterocolitis or suspected necrotising enterocolitis when receiving an EHM diet after surgical palliation compared to non-protocolised feeding with bovine formula.

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来源期刊

Cardiology in the Young 医学-小儿科

CiteScore

1.70

自引率

10.00%

发文量

715

审稿时长

4-8 weeks

期刊介绍： Cardiology in the Young is devoted to cardiovascular issues affecting the young, and the older patient suffering the sequels of congenital heart disease, or other cardiac diseases acquired in childhood. The journal serves the interests of all professionals concerned with these topics. By design, the journal is international and multidisciplinary in its approach, and members of the editorial board take an active role in the its mission, helping to make it the essential journal in paediatric cardiology. All aspects of paediatric cardiology are covered within the journal. The content includes original articles, brief reports, editorials, reviews, and papers devoted to continuing professional development.