模拟术前应激时接受手术的实验鼠的心理情绪表现特征

IF 0.9 4区医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL

Bulletin of Experimental Biology and Medicine Pub Date : 2024-09-01 Epub Date: 2024-10-01 DOI:10.1007/s10517-024-06248-z

M V Kondashevskaya, V V Aleksankina, K A Artemyeva, K A Kasabov

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引用次数: 0

摘要

我们研究了性成熟雄性 C57BL/6 小鼠（n=40）的心理情感特征和血液中皮质酮的水平：完整（对照组）、模拟术前应激和手术后、手术后和单独麻醉后。结果发现，根据高架加迷宫测试计算出的焦虑指数在两组手术动物中都明显较高。手术组和单纯麻醉组的小鼠都表现出更高的焦虑。有记录表明，焦虑极有可能转变为精神情绪失调。

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Characteristics of Psychoemotional Manifestations of Laboratory Rodents Undergoing Surgery when Modeling Preoperative Stress.

We studied psychoemotional characteristics and the blood level of corticosterone in sexually mature male C57BL/6 mice (n=40): intact (control), after simulating preoperative stress and surgery, after surgery, and after anesthesia alone. It was found that the anxiety index calculated on the basis of testing in the elevated plus maze was significantly higher in both groups of operated animals. The mice of both operated groups and animals exposed to anesthesia alone showed increased anxiety. Symptoms indicating a high probability of transition of anxiety into a psychoemotional disorder have been recorded.

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来源期刊

Bulletin of Experimental Biology and Medicine 医学-医学：研究与实验

CiteScore

1.50

自引率

14.30%

发文量

265

审稿时长

2 months

期刊介绍： Bulletin of Experimental Biology and Medicine presents original peer reviewed research papers and brief reports on priority new research results in physiology, biochemistry, biophysics, pharmacology, immunology, microbiology, genetics, oncology, etc. Novel trends in science are covered in new sections of the journal - Biogerontology and Human Ecology - that first appeared in 2005. World scientific interest in stem cells prompted inclusion into Bulletin of Experimental Biology and Medicine a quarterly scientific journal Cell Technologies in Biology and Medicine (a new Russian Academy of Medical Sciences publication since 2005). It publishes only original papers from the leading research institutions on molecular biology of stem and progenitor cells, stem cell as the basis of gene therapy, molecular language of cell-to-cell communication, cytokines, chemokines, growth and other factors, pilot projects on clinical use of stem and progenitor cells. The Russian Volume Year is published in English from April.