心绞痛、心肌梗死和心房颤动的关联--双向孟德尔随机研究

IF 1 4区 医学 Q3 MEDICINE, GENERAL & INTERNAL
British journal of hospital medicine Pub Date : 2024-09-30 Epub Date: 2024-09-13 DOI:10.12968/hmed.2024.0137
Lu Chen, Yan He, Ying Wang, Shijing Liu, Qing Li, Jiyu Chen, Zhiyun Peng, Qian Zhang, Chen Zeng, Na Li, Yan Zeng, Yun Xiong, Wei Li, Haiyan Zhou
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引用次数: 0

摘要

目的/背景 冠心病(CHD)与心房颤动(AF)关系密切,但现有研究主要依赖于观察性研究方法,这给建立因果关系带来了挑战。我们的研究旨在探讨冠状动脉粥样硬化(CAA)、心绞痛、心肌梗死(MI)和心房颤动之间的因果关系。方法 本研究采用双样本孟德尔随机化(TSMR)方法,利用遗传变异评估因果关系。孟德尔随机法基于三个主要假设:(1)基因变异与暴露相关;(2)基因变异独立于混杂因素;(3)基因变异仅通过暴露影响结果。结果 我们的研究结果表明,在遗传易感性中,CAA、心绞痛和心肌梗死可能会增加心房颤动的易感性,而心房颤动可能会相互提高 CAA 的风险。结论 鉴于这些研究结果,建议患有心脏病的患者定期接受心律监测,患有房颤的患者在可行的情况下接受抗凝和抗血小板治疗。本研究对临床实践具有实际意义。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Association of Angina, Myocardial Infarction and Atrial Fibrillation-A Bidirectional Mendelian Randomization Study.

Aims/Background Coronary heart disease (CHD) and atrial fibrillation (AF) exhibit a close relationship, yet the existing body of research predominantly relies on observational study methodologies, posing challenges in establishing causal relationships. The objective of our study is to investigate the causal linkages between coronary atherosclerosis (CAAs), angina pectoris, myocardial infarction (MI), and AF. Methods This study utilizes a two-sample Mendelian randomization (TSMR) methodology, leveraging genetic variation as a means of evaluating causality. Mendelian randomization is grounded in three primary assumptions: (1) the genetic variant is linked to the exposure, (2) the genetic variant is independent of confounding factors, and (3) the genetic variant influences the outcome solely through the exposure. Results The results of our study suggest a genetic predisposition in which CAAs, angina, and MI may enhance susceptibility to AF, while AF may reciprocally elevate the risk of CAAs. Conclusion In light of these findings, it is recommended that patients with CHD undergo regular cardiac rhythm monitoring, and that patients with AF receive anticoagulant and antiplatelet therapy whenever feasible. This study posits a practical implication for clinical practice.

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来源期刊
British journal of hospital medicine
British journal of hospital medicine 医学-医学:内科
CiteScore
1.50
自引率
0.00%
发文量
176
审稿时长
4-8 weeks
期刊介绍: British Journal of Hospital Medicine was established in 1966, and is still true to its origins: a monthly, peer-reviewed, multidisciplinary review journal for hospital doctors and doctors in training. The journal publishes an authoritative mix of clinical reviews, education and training updates, quality improvement projects and case reports, and book reviews from recognized leaders in the profession. The Core Training for Doctors section provides clinical information in an easily accessible format for doctors in training. British Journal of Hospital Medicine is an invaluable resource for hospital doctors at all stages of their career. The journal is indexed on Medline, CINAHL, the Sociedad Iberoamericana de Información Científica and Scopus.
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