乌干达感染艾滋病毒的老年人中肾功能损害的发病率较高。

IF 2.2 4区 医学 Q2 UROLOGY & NEPHROLOGY
Amutuhaire Judith Ssemasaazi, Robert Kalyesubula, Yukari C Manabe, Phoebe Mbabazi, Susan Naikooba, Faizo Ssekindi, Esther Nasuuna, Pauline Byakika-Kibwika, Barbara Castelnuovo
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引用次数: 0

摘要

背景:艾滋病病毒感染者(PLWH)有可能因艾滋病相关炎症、抗逆转录病毒疗法(ART)、糖尿病和高血压而导致肾功能受损。随着年龄的增长,肾功能也会下降,因此老年人患慢性肾脏病(CKD)的负担可能会更重。在撒哈拉以南非洲地区,将老年 PLWH 与未感染 HIV 的人群的肾功能损害患病率进行比较的数据很少:我们在乌干达坎帕拉对年龄≥ 60 岁的艾滋病病毒感染者和非艾滋病病毒感染者进行了一项横断面研究,并按社区位置进行了 1:1 匹配。我们收集了有关社会人口学、合并症和 HIV 相关临床特征的数据。我们将肾功能损害定义为估计肾小球滤过率(eGFR)为 2 且伴有或不伴有蛋白尿。我们建立了多变量逻辑回归模型来研究参与者特征与肾功能损害之间的关系:我们共招募了 278 人(中位年龄为 66 岁),其中 50% 为 PLWH,51.8% 为女性。在 PLWH 中,33.1%(95% CI:25.7-41.4%)的人患有肾功能损害,而在未感染 HIV 的人中,这一比例为 12.9%(95% CI:8.3-19.7%)(P 值 结论:HIV 感染与肾功能损害密切相关:在老年 PLWH 中,HIV 感染与肾功能损害密切相关。优先考虑对老年 PLWH 的肾功能和蛋白尿进行常规测量,将有助于及早发现并采取措施减少肾脏疾病的恶化。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Higher prevalence of kidney function impairment among older people living with HIV in Uganda.

Background: People living with HIV (PLWH) are at risk of kidney function impairment due to HIV-related inflammation, antiretroviral therapy (ART), diabetes mellitus, and hypertension. Older persons may experience a higher burden of chronic kidney disease (CKD) as kidney function declines with increasing age. There is a paucity of data comparing the prevalence of kidney function impairment in older PLWH to that in people without HIV in sub-Saharan Africa.

Methods: We conducted a cross-sectional study among people aged ≥ 60 years living with and without HIV in Kampala, Uganda who were matched 1:1 by community location. We collected data on sociodemographics, comorbidities, and HIV-related clinical characteristics. We defined kidney function impairment as an estimated glomerular filtration rate(eGFR) < 60mls/min/1.73m2 with or without proteinuria. We constructed multivariable logistic regression models to study associations between participant characteristics and kidney function impairment.

Results: We enrolled 278 people (median age 66 years); 50% were PLWH, and 51.8% were female. Among PLWH, 33.1% (95% CI: 25.7-41.4%) had kidney function impairment versus 12.9% (95% CI: 8.3-19.7%) among people without HIV, (p-value < 0.01). The prevalence of proteinuria among PLWH versus people without HIV was 43.9% (95% CI:35.8-52.3%) versus 19.4% (95% CI:13.6-26.9%) p-value < 0.01. Living with HIV (OR = 3.89(95% CI: 2.04-7.41), p-value < 0.01), older age (OR = 1.13, (95% CI:1.07-1.20), p-value < 0.01), female sex (OR = 1.95, (95% CI:1.06-3.62), p-value = 0.03) and a prior diagnosis of hypertension (OR = 2.19(95% CI:1.02-4.67), p-value = 0.04) were significantly associated with kidney function impairment.

Conclusions: HIV infection is strongly associated with kidney function impairment among older PLWH. Prioritizing routine measurements of kidney function and proteinuria in older PLWH will enable early detection and institution of measures to reduce the progression of kidney disease.

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来源期刊
BMC Nephrology
BMC Nephrology UROLOGY & NEPHROLOGY-
CiteScore
4.30
自引率
0.00%
发文量
375
审稿时长
3-8 weeks
期刊介绍: BMC Nephrology is an open access journal publishing original peer-reviewed research articles in all aspects of the prevention, diagnosis and management of kidney and associated disorders, as well as related molecular genetics, pathophysiology, and epidemiology.
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