慢性肾病患儿脑源性神经营养因子和鸢尾素浓度评估:一项试点研究。

IF 2.2 4区 医学 Q2 UROLOGY & NEPHROLOGY
Aleksandra Gliwińska, Marta Badeńska, Marta Dworak, Elżbieta Świętochowska, Andrzej Badeński, Omar Bjanid, Elżbieta Trembecka-Dubel, Aurelia Morawiec-Knysak, Maria Szczepańska
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引用次数: 0

摘要

慢性肾脏病(CKD)患者尤其容易出现多器官并发症。其中一种并发症是营养不良,这种并发症会增加患者的死亡率。本研究旨在确定脑源性神经营养因子(BDNF)和鸢尾素测定在评估 CKD 发展过程中的作用。研究组包括 28 名接受保守治疗的 2-5 期 CKD 患儿。研究结果显示,与健康对照组相比,CKD 患者血清中的 BDNF 和鸢尾素水平降低,而尿液中的 BDNF 浓度升高,鸢尾素浓度降低。在研究组中,人体测量指标与尿液中的 BDNF 浓度呈正相关,人体测量指标与血清和尿液中的鸢尾素水平也呈正相关,但未观察到测试指标与 CKD 阶段的相关性。近年来,肌动蛋白在维持代谢平衡方面发挥了重要作用,因此我们认为这些多方面的标记物在检测 CKD 儿童营养不良方面具有潜在作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Assessment of brain-derived neurotrophic factor and irisin concentration in children with chronic kidney disease: a pilot study.

Patients suffering from chronic kidney disease (CKD) are particularly placed at risk of multiorgan complications. One of them is malnutrition, which adds up to a higher mortality factor among them. This study was designed to determine the usefulness of brain-derived neurotrophic factor (BDNF) and irisin assays in the assessment of CKD development. The study group included 28 children with CKD at stages 2-5 treated conservatively. The outcome of our study revealed decreased serum BDNF and irisin levels in CKD patients, whereas urine concentrations were increased for BDNF and decreased for irisin, comparing to healthy controls. There was a positive correlation between anthropometric measures and urine BDNF concentration, as well as anthropometric measures and both serum and urine irisin levels in the study group, however no dependence of the tested markers on the stage of CKD was observed. In recent years, a role of myokines was described as vital for maintaining metabolic homeostasis therefore we suspect a potential role of these multifaceted markers in detecting malnutrition in CKD children.

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来源期刊
BMC Nephrology
BMC Nephrology UROLOGY & NEPHROLOGY-
CiteScore
4.30
自引率
0.00%
发文量
375
审稿时长
3-8 weeks
期刊介绍: BMC Nephrology is an open access journal publishing original peer-reviewed research articles in all aspects of the prevention, diagnosis and management of kidney and associated disorders, as well as related molecular genetics, pathophysiology, and epidemiology.
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