设计条件性蛋白质-蛋白质相互作用,实现动态细胞控制。

IF 12.1 1区 工程技术 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Anthony M. Stohr, Derron Ma, Wilfred Chen, Mark Blenner
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引用次数: 0

摘要

条件性蛋白质-蛋白质相互作用能够对细胞活动进行动态调控,是探究原生蛋白质相互作用、改进微生物工厂代谢工程和开发智能疗法的一种极具吸引力的方法。有条件的蛋白质-蛋白质相互作用已被设计成能对各种化学、光和核酸刺激做出反应。这些相互作用已被用于组装蛋白质片段、构建蛋白质支架,以及在许多微生物和高阶宿主体内组织蛋白质。为了促进新型条件蛋白质-蛋白质相互作用的发展,以应对新的输入或在其他环境中加以利用,我们概述了设计新的工程蛋白质相互作用的过程,同时展示了许多最近开发的计算工具,这些工具可能会加速这一领域的蛋白质工程。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Engineering conditional protein-protein interactions for dynamic cellular control
Conditional protein-protein interactions enable dynamic regulation of cellular activity and are an attractive approach to probe native protein interactions, improve metabolic engineering of microbial factories, and develop smart therapeutics. Conditional protein-protein interactions have been engineered to respond to various chemical, light, and nucleic acid-based stimuli. These interactions have been applied to assemble protein fragments, build protein scaffolds, and spatially organize proteins in many microbial and higher-order hosts. To foster the development of novel conditional protein-protein interactions that respond to new inputs or can be utilized in alternative settings, we provide an overview of the process of designing new engineered protein interactions while showcasing many recently developed computational tools that may accelerate protein engineering in this space.
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来源期刊
Biotechnology advances
Biotechnology advances 工程技术-生物工程与应用微生物
CiteScore
25.50
自引率
2.50%
发文量
167
审稿时长
37 days
期刊介绍: Biotechnology Advances is a comprehensive review journal that covers all aspects of the multidisciplinary field of biotechnology. The journal focuses on biotechnology principles and their applications in various industries, agriculture, medicine, environmental concerns, and regulatory issues. It publishes authoritative articles that highlight current developments and future trends in the field of biotechnology. The journal invites submissions of manuscripts that are relevant and appropriate. It targets a wide audience, including scientists, engineers, students, instructors, researchers, practitioners, managers, governments, and other stakeholders in the field. Additionally, special issues are published based on selected presentations from recent relevant conferences in collaboration with the organizations hosting those conferences.
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