关于 Ethan M. Alt、Xiuya Chang、Xun Jiang、Qing Liu、May Mo、H. Amy Xia 和 Joseph G. Ibrahim 所著《LEAP：从历史数据中借用信息的潜在可交换性先验》的讨论。

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-07-01 DOI:10.1093/biomtc/ujae085

Darren Scott, Alex Lewin

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引用次数: 0

摘要

在下面的讨论中，我们将介绍在贝叶斯借用和相关模型中对可交换性所做的各种假设。在此背景下，我们能够强调在历史数据中的个体与当前数据可交换的假设下动态贝叶斯借用的困难，从而突出潜在可交换性先验的优势和新特点。由于借用方法在临床试验中常用于增强对照组，因此我们发现了在这种情况下应用该方法可能面临的一些挑战。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Discussion on "LEAP: the latent exchangeability prior for borrowing information from historical data" by Ethan M. Alt, Xiuya Chang, Xun Jiang, Qing Liu, May Mo, H. Amy Xia, and Joseph G. Ibrahim.

In the following discussion, we describe the various assumptions of exchangeability that have been made in the context of Bayesian borrowing and related models. In this context, we are able to highlight the difficulty of dynamic Bayesian borrowing under the assumption of individuals in the historical data being exchangeable with the current data and thus the strengths and novel features of the latent exchangeability prior. As borrowing methods are popular within clinical trials to augment the control arm, some potential challenges are identified with the application of the approach in this setting.

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.