赋予细菌细胞壁可变性和适应性的机制

IF 3.8 3区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biochemical Society transactions Pub Date : 2024-10-30 DOI:10.1042/BST20230027

Gabriel Torrens, Felipe Cava

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引用次数: 0

摘要

细菌细胞壁是一种复杂而动态的结构，主要由肽聚糖（PG）组成，在细菌的生存和适应中发挥着关键作用。细菌通过编辑肽聚糖成分积极改造细胞壁，以应对环境挑战。肽组成、交联模式和糖链结构的多种变化使细菌有能力抵抗抗生素、躲避宿主免疫检测并适应动态环境。这篇综述全面总结了迄今为止报道的最常见修饰及其相关的适应作用，并进一步强调了对 PG 合成和周转的调控是如何提供抗细胞溶解的能力的。

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Mechanisms conferring bacterial cell wall variability and adaptivity.

The bacterial cell wall, a sophisticated and dynamic structure predominantly composed of peptidoglycan (PG), plays a pivotal role in bacterial survival and adaptation. Bacteria actively modify their cell walls by editing PG components in response to environmental challenges. Diverse variations in peptide composition, cross-linking patterns, and glycan strand structures empower bacteria to resist antibiotics, evade host immune detection, and adapt to dynamic environments. This review comprehensively summarizes the most common modifications reported to date and their associated adaptive role and further highlights how regulation of PG synthesis and turnover provides resilience to cell lysis.

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来源期刊

Biochemical Society transactions 生物-生化与分子生物学

CiteScore

7.80

自引率

0.00%

发文量

351

审稿时长

3-6 weeks

期刊介绍： Biochemical Society Transactions is the reviews journal of the Biochemical Society. Publishing concise reviews written by experts in the field, providing a timely snapshot of the latest developments across all areas of the molecular and cellular biosciences. Elevating our authors’ ideas and expertise, each review includes a perspectives section where authors offer comment on the latest advances, a glimpse of future challenges and highlighting the importance of associated research areas in far broader contexts.