中草药对早产儿喂养不耐受的疗效:系统回顾与元分析》。

IF 1.9 4区 医学 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE
Eun-Jin Kim, Ji-U Choi, Sang Yeon Min
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引用次数: 0

摘要

背景:喂养不耐受(FI)是指频繁的喂养中断,会对早产儿(妊娠37周以下出生)的生长、营养状况和长期神经发育结果产生不利影响。本综述评估了中草药(HM)与传统疗法相比对早产儿的疗效:方法:从 2023 年 8 月 1 日至 12 月 7 日,我们对 11 个数据库进行了广泛检索,包括英文、中文和韩文数据库。我们的纳入标准是随机临床试验(RCT),这些试验比较了中药与常规治疗和单纯常规治疗的疗效。统计分析包括计算平均差(MD)、标准化平均差(SMD)、风险比(RR)及95%置信区间(CI),并使用Review Manager Version 5.4软件评估偏倚风险(RoB 2)。证据质量采用建议评估、发展和评价分级(GRADE)系统进行评估:荟萃分析表明,HM 综合疗法的疗效优于单独的常规疗法。使用 HM 后,实现完全肠内喂养的时间(n = 638,随机效应 MD:-2.91,95% CI:-4.13 至-1.69)、FI 持续时间(n = 366,固定效应 MD:-1.58,95% CI:-2.01 至-1.16)和总有效率(n = 774,随机效应 RR:1.26,95% CI:1.11 至 1.42)均有所改善。腹泻和排便次数增加等轻度不良反应在HM联合治疗组中发生率为4.17%,而在常规治疗组中发生率为1.42%:结论:研究结果表明,将 HM 与常规治疗相结合对 FI 更为有效,这表明 HM 可作为早产儿 FI 的早期干预措施。有必要对早产儿使用 HM 的有效性和安全性进行进一步研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Effectiveness of Herbal Medicine on Feeding Intolerance in Preterm Infants: A Systematic Review and Meta-Analysis.

Background: Feeding intolerance (FI) refers to frequent feeding disruptions, that can adversely affect the growth, nutritional status, and long-term neurodevelopmental outcomes of preterm infants (born at 37 ≤ weeks of gestation). This review evaluated the efficacy of herbal medicine (HM) for FI compared to conventional treatments.

Methods: An extensive search across 11 databases was conducted, including English, Chinese, and Korean databases, from August 1 to December 7, 2023. Our inclusion criteria were randomized clinical trials (RCTs) that compared the efficacy of HM with conventional treatments against conventional treatments alone. Statistical analyses involved calculating the mean difference (MD), standardized mean difference (SMD), and risk ratio (RR) with a 95% confidence interval (CI), and assessing the bias risk (RoB 2) using Review Manager Version 5.4 software. The quality of evidence was evaluated using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) rating system.

Results: The meta-analysis showed that combined HM treatments exhibited superior outcomes compared to conventional treatments alone. The time to achieve full enteral feeding (n = 638, random effects MD: -2.91, 95% CI: -4.13 to -1.69), duration of FI (n = 366, fixed effects MD: -1.58, 95% CI: -2.01 to -1.16), and total effective rate (n = 774, random effects RR: 1.26, 95% CI: 1.11 to 1.42) improved with HM. Mild adverse events, such as diarrhea and increased defecation frequency, occurred in 4.17% of the HM combined group, compared to 1.42% in the conventional treatment group.

Conclusions: The findings suggest that combining HM with conventional treatments could be more effective for FI, suggesting HM as an early intervention for FI in preterm infants. Further research on the efficacy and safety of HM in preterm infants is necessary.

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来源期刊
Alternative therapies in health and medicine
Alternative therapies in health and medicine INTEGRATIVE & COMPLEMENTARY MEDICINE-
CiteScore
0.90
自引率
0.00%
发文量
219
期刊介绍: Launched in 1995, Alternative Therapies in Health and Medicine has a mission to promote the art and science of integrative medicine and a responsibility to improve public health. We strive to maintain the highest standards of ethical medical journalism independent of special interests that is timely, accurate, and a pleasure to read. We publish original, peer-reviewed scientific articles that provide health care providers with continuing education to promote health, prevent illness, and treat disease. Alternative Therapies in Health and Medicine was the first journal in this field to be indexed in the National Library of Medicine. In 2006, 2007, and 2008, ATHM had the highest impact factor ranking of any independently published peer-reviewed CAM journal in the United States—meaning that its research articles were cited more frequently than any other journal’s in the field. Alternative Therapies in Health and Medicine does not endorse any particular system or method but promotes the evaluation and appropriate use of all effective therapeutic approaches. Each issue contains a variety of disciplined inquiry methods, from case reports to original scientific research to systematic reviews. The editors encourage the integration of evidence-based emerging therapies with conventional medical practices by licensed health care providers in a way that promotes a comprehensive approach to health care that is focused on wellness, prevention, and healing. Alternative Therapies in Health and Medicine hopes to inform all licensed health care practitioners about developments in fields other than their own and to foster an ongoing debate about the scientific, clinical, historical, legal, political, and cultural issues that affect all of health care.
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