Advances in covalent organic frameworks for sample preparation

Sample preparation is crucial in analytical chemistry, impacting result accuracy, sensitivity, and reliability. Solid-phase separation media, especially adsorbents, are vital for preparing of liquid and gas samples, commonly analyzed by most analytical instruments. With the advancements in materials science, covalent organic frameworks (COFs) constructed through strong covalent bonds, have been increasingly employed in sample preparation in recent years. COFs have outstanding selectivity and/or excellent adsorption capacity for a single target or can selectively adsorb multiple targets from complex matrix, due to their large specific surface area, adjustable pore size, easy modification, and stable chemical properties. In this review, we summarize the classification of COFs, such as pristine COFs, COF composite particles, and COFs-based substrates. We aim to provide a comprehensive understanding of the different classifications of COFs in sample preparation within the last three years. The challenges and development trends of COFs in sample preparation are also presented.