一项针对急性肠胃炎住院患者的多病原体回顾性研究。

IF 2.9 Q2 MEDICINE, RESEARCH & EXPERIMENTAL
Antonella Zizza, Marcello Guido, Raffaella Sedile, Marzia Benelli, Milva Nuzzo, Pasquale Paladini, Anacleto Romano, Pierfrancesco Grima
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引用次数: 0

摘要

急性肠胃炎(AGE)是一种胃肠道疾病,通常由食用被细菌、病毒或寄生虫污染的食物或水引起,可导致严重症状,需要住院治疗。莱切医院儿科和传染科对2021年至2023年间因急性胃肠炎入院的患者进行了一项回顾性研究。研究收集了患者的人口统计学特征、入院年月、住院时间、病原体、合并感染和血液化学数据。研究共纳入 103 名患者,年龄从 0 岁到 15 岁不等,其中 58.25% 为男性。共发现 78 种细菌感染、35 种病毒感染和 7 种寄生虫感染。最常检测到的病原体是大肠杆菌(38.83%)、诺如病毒(28.16%)、空肠弯曲杆菌(22.33%)和伤寒沙门氏菌/副伤寒(10.68%)。只有少数病例发现了隐孢子虫(5.83%)。此外,还发现了 17 例合并感染病例(16.50%)。病毒感染是导致儿童因 AGE 住院的主要原因
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A Multi-Pathogen Retrospective Study in Patients Hospitalized for Acute Gastroenteritis.

Acute gastroenteritis (AGE) is a gastrointestinal tract disease often caused by consuming food or water contaminated by bacteria, viruses, or parasites, that can lead to severe symptoms requiring hospitalization. A retrospective study on patients admitted for AGE between 2021 and 2023 at the Pediatrics and Infectious Diseases Departments of Lecce Hospital was conducted. Demographic characteristics, year and month of admission, length of hospital stay, etiological agents, co-infections, and blood chemistry data of patients were collected. The study included 103 patients ranging in age from 0 to 15 years, with 58.25% being male. A total of 78 bacterial, 35 viral, and 7 parasitic infections were identified. The most commonly detected pathogens were Escherichia coli (38.83%), Norovirus (28.16%), Campylobacter jejuni (22.33%), and Salmonella typhi/paratyphi (10.68%). Only a few cases of Cryptosporidium (5.83%) were identified. Additionally, 17 co-infections (16.50%) were detected. Viral infections are the primary cause of hospitalization for AGE in children <5 years, while bacterial infections are more common among older patients. The significantly higher number of children <5 years old with elevated creatinine compared to children ≥5 years suggested that young children are more susceptible to dehydration than older children. Few cases of AGE were attributed to pathogens for which a vaccine has already been licensed. AGE is a serious health concern that could be effectively prevented by implementing food-based and community-level sanitation systems, as well as by increasing vaccination coverage of available vaccines and developing new effective and safe vaccines.

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