用于口服熊果酸的 pH 值响应性水凝胶:一种五环三萜类植物化学物质。

IF 5 3区 化学 Q1 POLYMER SCIENCE
Gels Pub Date : 2024-09-22 DOI:10.3390/gels10090602
Carlos D Gutierrez, Rosana L Aranzábal, Ana M Lechuga, Carlos A Serrano, Flor Meza, Carlos Elvira, Alberto Gallardo, Michael A Ludeña
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引用次数: 0

摘要

本研究通过聚乙二醇甲基醚甲基丙烯酸酯(PEGxMEM)、甲基丙烯酸 2-羟乙基酯(HEMA)和衣康酸(IA)的自由基共聚制备了聚(HEMA-PEGxMEM-IA)水凝胶。以 N,N'-亚甲基双丙烯酰胺(MBA)为交联剂,1-羟基环己基苯基酮(HCPK)为光引发剂,在乙醇溶液中进行反应。聚(HEMA-PEGxMEM-IA)水凝胶(HGx)被评估为熊果酸(UA)的输送系统,熊果酸是从 "flor de arena "植物 Clinopodium revolutum 中提取的一种植物化学物质。傅立叶变换红外光谱(FTIR-ATR)、拉曼光谱、X 射线衍射(XRD)、热重分析(TGA)和扫描电子显微镜(SEM)对水凝胶进行了表征。研究了水凝胶在 pH 值为 2 到 10 的缓冲溶液中的溶胀行为,特别是在 pH 值为 2.2(胃环境)和 7.4(肠道环境)时的溶胀行为。研究发现,所研究的水凝胶对 pH 值非常敏感。在 pH 值为 2.2 时,HG5 和 HG9 水凝胶的溶胀度分别为 0.45 和 0.93(克水/克水凝胶)。在 pH 值为 7.4 时,HG5 和 HG9 水凝胶的溶胀度分别为 1.97 和 2.64(克水/克水凝胶)。扫描电镜图像显示了孔隙大小随 pH 值的变化,还可以观察到水凝胶孔隙中的尿素结晶。UA 的体外释放数据最符合 Korsmeyer-Peppas 动力学模型,扩散指数表明释放机制受 Fickian 扩散的支配。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A pH-Responsive Hydrogel for the Oral Delivery of Ursolic Acid: A Pentacyclic Triterpenoid Phytochemical.

In this study, poly(HEMA-PEGxMEM-IA) hydrogels were prepared by radical copolymerization of poly(ethylene glycol) methyl ether methacrylate (PEGxMEM), 2-hydroxyethyl methacrylate (HEMA), and itaconic acid (IA). The reaction was carried out in ethanolic solution using N,N'-methylenebisacrylamide (MBA) as a crosslinking agent and 1-hydroxycyclohexyl phenyl ketone (HCPK) as a photo-initiator. The poly(HEMA-PEGxMEM-IA) hydrogels (HGx) were evaluated as a delivery system for ursolic acid (UA), a phytochemical extracted from the plant Clinopodium revolutum, "flor de arena". The hydrogels were characterized by Fourier-transform infrared spectroscopy (FTIR-ATR), Raman spectroscopy, X-Ray diffraction (XRD), thermogravimetric analysis (TGA), and scanning electron microscopy (SEM). The swelling behavior was studied in buffer solutions from pH 2 to 10, specifically at pH 2.2 (gastric environment) and 7.4 (intestinal environment). It was found that the hydrogels studied showed sensitivity to pH. At pH 2.2, the degree of swelling for HG5 and HG9 hydrogels was 0.45 and 0.93 (g water/g hydrogel), respectively. At pH 7.4, the degree of swelling for HG5 and HG9 hydrogels was 1.97 and 2.64 (g water/g hydrogel), respectively. The SEM images show the variation in pore size as a function of pH, and the UA crystals in the pores of the hydrogels can also be observed. The in vitro UA release data best fit the Korsmeyer-Peppas kinetic model and the diffusion exponent indicates that the release mechanism is governed by Fickian diffusion.

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来源期刊
Gels
Gels POLYMER SCIENCE-
CiteScore
4.70
自引率
19.60%
发文量
707
审稿时长
11 weeks
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