关于类黄酮对慢性肾脏病患者动脉僵化和氧化应激影响的试点研究。

Anastasia Vagopoulou, Panagiotis Theofilis, Despina Karasavvidou, Nasra Haddad, Dimitris Makridis, Stergios Tzimikas, Rigas Kalaitzidis
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引用次数: 0

摘要

背景:目的:前瞻性研究类黄酮对慢性肾脏病(CKD)I-IV期患者动脉僵化的影响:在这项前瞻性单臂研究中,招募了患有动脉高血压和糖尿病的慢性肾脏病患者。记录了基线人口统计学、临床和实验室变量。患者每天接受富含苯酚的膳食补充剂治疗,为期 3 个月。在基线和研究结束时测量血压、动脉僵化(颈动脉-股动脉脉搏波速度、中心脉压)和氧化应激指标(蛋白质羰基、总酚化合物、总抗氧化能力):16 名患者(平均年龄 62.5 岁,87.5% 为男性)完成了研究。干预后,外周收缩压明显降低了 14 mmHg(P < 0.001)。颈动脉-股动脉脉搏波速度从 8.9 米/秒(基线)降至 8.2 米/秒(研究结束时)(P < 0.001),中心脉压从 59 毫米汞柱降至 48 毫米汞柱(P = 0.003)。类黄酮还能降低氧化应激指标,包括蛋白质羰基(P < 0.001)、总酚化合物(P = 0.001)和总抗氧化能力(P = 0.013):结论:为慢性肾脏病患者补充类黄酮有望改善血压、动脉僵化和氧化应激指标。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Pilot study on the effect of flavonoids on arterial stiffness and oxidative stress in chronic kidney disease.

Background: Flavonoids, the main class of polyphenols, exhibit antioxidant and antihypertensive properties.

Aim: To prospectively investigate the impact of flavonoids on arterial stiffness in patients with chronic kidney disease (CKD) stages I-IV.

Methods: In this prospective, single-arm study, CKD patients with arterial hypertension and diabetes mellitus were enrolled. Baseline demographic, clinical, and laboratory variables were recorded. Patients received daily treatment with a phenol-rich dietary supplement for 3 months. Blood pressure, arterial stiffness (carotid-femoral pulse wave velocity, central pulse pressure), and oxidative stress markers (protein carbonyls, total phenolic compound, total antioxidant capacity) were measured at baseline and at study end.

Results: Sixteen patients (mean age: 62.5 years, 87.5% male) completed the study. Following intervention, peripheral systolic blood pressure decreased significantly by 14 mmHg (P < 0.001). Carotid-femoral pulse wave velocity decreased from 8.9 m/s (baseline) to 8.2 m/s (study end) (P < 0.001), and central pulse pressure improved from 59 mmHg to 48 mmHg (P = 0.003). Flavonoids also reduced oxidative stress markers including protein carbonyls (P < 0.001), total phenolic compound (P = 0.001), and total antioxidant capacity (P = 0.013).

Conclusion: Flavonoid supplementation in CKD patients shows promise in improving blood pressure, arterial stiffness, and oxidative stress markers.

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