Irene Soler-Sáez , Alcida Karz , Marta R. Hidalgo , Borja Gómez-Cabañes , Adolfo López-Cerdán , José F. Català-Senent , Kylie Prutisto-Chang , Nicole M. Eskow , Benjamin Izar , Torben Redmer , Swaminathan Kumar , Michael A. Davies , María de la Iglesia-Vayá , Eva Hernando , Francisco García-García
{"title":"揭示黑色素瘤脑转移瘤与神经退行性疾病的共同转录组特征","authors":"Irene Soler-Sáez , Alcida Karz , Marta R. Hidalgo , Borja Gómez-Cabañes , Adolfo López-Cerdán , José F. Català-Senent , Kylie Prutisto-Chang , Nicole M. Eskow , Benjamin Izar , Torben Redmer , Swaminathan Kumar , Michael A. Davies , María de la Iglesia-Vayá , Eva Hernando , Francisco García-García","doi":"10.1016/j.jid.2024.09.005","DOIUrl":null,"url":null,"abstract":"<div><div>Melanoma represents a critical clinical challenge owing to its unfavorable outcomes. This type of skin cancer exhibits unique adaptability to the brain microenvironment, but its underlying molecular mechanisms are poorly understood. Recent findings have suggested that melanoma brain metastases may share biological processes similar to those found in various neurodegenerative diseases. To further characterize melanoma brain metastasis development, we explore the relationship between the transcriptional profiles of melanoma brain metastases and the neurodegenerative diseases Alzheimer's disease, Parkinson's disease, and multiple sclerosis. We take an in silico approach to unveil a neurodegenerative signature of melanoma brain metastases compared with those of melanoma nonbrain metastasis (53 dysregulated genes were enriched in 11 functional terms, such as associated terms to the extracellular matrix and development) and with those of nontumor-bearing brain controls (195 dysregulated genes, mostly involved in development and cell differentiation, chromatin remodeling and nucleosome organization, and translation). Two genes, <em>ITGA10</em> and <em>DNAJC6</em>, emerged as key potential markers being dysregulated in both scenarios. Finally, we developed an open-source, user-friendly web tool (<span><span>https://bioinfo.cipf.es/metafun-mbm/</span><svg><path></path></svg></span>) that allows interactive exploration of the complete results.</div></div>","PeriodicalId":16311,"journal":{"name":"Journal of Investigative Dermatology","volume":"145 5","pages":"Pages 1135-1146"},"PeriodicalIF":5.7000,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Unveiling Common Transcriptomic Features between Melanoma Brain Metastases and Neurodegenerative Diseases\",\"authors\":\"Irene Soler-Sáez , Alcida Karz , Marta R. Hidalgo , Borja Gómez-Cabañes , Adolfo López-Cerdán , José F. Català-Senent , Kylie Prutisto-Chang , Nicole M. Eskow , Benjamin Izar , Torben Redmer , Swaminathan Kumar , Michael A. Davies , María de la Iglesia-Vayá , Eva Hernando , Francisco García-García\",\"doi\":\"10.1016/j.jid.2024.09.005\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Melanoma represents a critical clinical challenge owing to its unfavorable outcomes. This type of skin cancer exhibits unique adaptability to the brain microenvironment, but its underlying molecular mechanisms are poorly understood. Recent findings have suggested that melanoma brain metastases may share biological processes similar to those found in various neurodegenerative diseases. To further characterize melanoma brain metastasis development, we explore the relationship between the transcriptional profiles of melanoma brain metastases and the neurodegenerative diseases Alzheimer's disease, Parkinson's disease, and multiple sclerosis. We take an in silico approach to unveil a neurodegenerative signature of melanoma brain metastases compared with those of melanoma nonbrain metastasis (53 dysregulated genes were enriched in 11 functional terms, such as associated terms to the extracellular matrix and development) and with those of nontumor-bearing brain controls (195 dysregulated genes, mostly involved in development and cell differentiation, chromatin remodeling and nucleosome organization, and translation). Two genes, <em>ITGA10</em> and <em>DNAJC6</em>, emerged as key potential markers being dysregulated in both scenarios. Finally, we developed an open-source, user-friendly web tool (<span><span>https://bioinfo.cipf.es/metafun-mbm/</span><svg><path></path></svg></span>) that allows interactive exploration of the complete results.</div></div>\",\"PeriodicalId\":16311,\"journal\":{\"name\":\"Journal of Investigative Dermatology\",\"volume\":\"145 5\",\"pages\":\"Pages 1135-1146\"},\"PeriodicalIF\":5.7000,\"publicationDate\":\"2024-09-24\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Investigative Dermatology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0022202X24021493\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"DERMATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Investigative Dermatology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0022202X24021493","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"DERMATOLOGY","Score":null,"Total":0}
Unveiling Common Transcriptomic Features between Melanoma Brain Metastases and Neurodegenerative Diseases
Melanoma represents a critical clinical challenge owing to its unfavorable outcomes. This type of skin cancer exhibits unique adaptability to the brain microenvironment, but its underlying molecular mechanisms are poorly understood. Recent findings have suggested that melanoma brain metastases may share biological processes similar to those found in various neurodegenerative diseases. To further characterize melanoma brain metastasis development, we explore the relationship between the transcriptional profiles of melanoma brain metastases and the neurodegenerative diseases Alzheimer's disease, Parkinson's disease, and multiple sclerosis. We take an in silico approach to unveil a neurodegenerative signature of melanoma brain metastases compared with those of melanoma nonbrain metastasis (53 dysregulated genes were enriched in 11 functional terms, such as associated terms to the extracellular matrix and development) and with those of nontumor-bearing brain controls (195 dysregulated genes, mostly involved in development and cell differentiation, chromatin remodeling and nucleosome organization, and translation). Two genes, ITGA10 and DNAJC6, emerged as key potential markers being dysregulated in both scenarios. Finally, we developed an open-source, user-friendly web tool (https://bioinfo.cipf.es/metafun-mbm/) that allows interactive exploration of the complete results.
期刊介绍:
Journal of Investigative Dermatology (JID) publishes reports describing original research on all aspects of cutaneous biology and skin disease. Topics include biochemistry, biophysics, carcinogenesis, cell regulation, clinical research, development, embryology, epidemiology and other population-based research, extracellular matrix, genetics, immunology, melanocyte biology, microbiology, molecular and cell biology, pathology, percutaneous absorption, pharmacology, photobiology, physiology, skin structure, and wound healing