在特发性肉芽肿性乳腺炎中使用皮质类固醇:系统综述。

IF 1.3 Q4 ONCOLOGY
Asel Wijesinghe, Kasun Lakmal, Jeewantha Senevirathna, Bhanu Wijetilake, J L T K Fernando, Umesh Jayarajah, Ajith De Silva, Kanchana Wijesinghe
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引用次数: 0

摘要

特发性肉芽肿性乳腺炎(IGM)是一种使人衰弱的慢性乳腺炎症。目前已有多项研究对局部注射类固醇(ILS)和局部使用类固醇治疗 IGM 进行了评估。然而,国际上对 IGM 的治疗缺乏共识。因此,我们对 ILS 治疗 IGM 的有效性进行了系统回顾。我们在 PubMed 和 Cochrane 图书馆数据库、谷歌学术网站上进行了系统检索,并在 2023 年 6 月 15 日前进行了引文检索。共筛选并分析了八篇文章。共有 397 名 IGM 患者被纳入研究。患者平均年龄为 35.7 岁,从 23 岁到 62 岁不等。治疗前病灶的平均直径为 27.5 毫米。共有 184 名患者接受了 ILS 治疗。平均完全临床反应时间为 2.6 个月。总体完全反应率为 92.8%。ILS 治疗后的并发症较少,常见的并发症有血肿、皮肤萎缩和充血,同时避免了口服类固醇药物的全身副作用,如体重增加和多毛症,而这些副作用是口服类固醇药物最常见的副作用。ILS 组的复发率(6.6%)似乎低于口服类固醇组(25.8%)和手术组(26.3%)。与其他干预策略相比,ILS似乎在完全反应率、完全临床反应时间、较低的复发率和并发症发生率等方面显示出良好的结果。然而,要确定 ILS 方案的最佳类型、剂量和频率,还需要进行更多标准化方案的比较研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Use of Intralesional Corticosteroids in Idiopathic Granulomatous Mastitis: A Systematic Review.

Idiopathic granulomatous mastitis (IGM) is a debilitating, chronic, inflammatory condition of the breast. Several studies have emerged evaluating intralesional steroid (ILS) injection and topical steroid administration as a treatment for IGM. However, there is a dearth of international consensuses with regards to the management of IGM. Therefore, we have systematically reviewed the effectiveness of ILS in the management of IGM. A systematic search was conducted in PubMed and Cochrane Library databases, the Google Scholar website and by citation searching up to June 15th, 2023. Eight articles were selected and analyzed. A total of 397 IGM patients were included in the review. The mean patient age was 35.7 years, ranging from 23-62 years. The mean pre-treatment diameter of lesions was 27.5 mm. A total of 184 patients were treated with ILS. The mean complete clinical response time was 2.6 months. The overall complete response rate was 92.8%. Complications following ILS were minor, with hematoma, skin atrophy and hyperemia being commonly described, while avoiding the systemic side effects of oral steroid use, such as weight gain and hirsutism, which were the most commonly reported side effects with oral steroids. The recurrence rates in the ILS group (6.6%) appear to be lower than in the oral steroid group (25.8%) and surgery group (26.3%). ILS seem to show a favorable outcome in terms of complete response rate, complete clinical response time and has a lower recurrence rate and complication rate when compared to other intervention strategies. However, more comparative studies with standardized protocols are necessary to ascertain the optimum type, dosage and frequency of ILS regimens.

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