亚麻籽对乳腺增生患者疼痛缓解和生活质量的影响:单臂干预研究

IF 1.3 Q4 ONCOLOGY
Tabish Ansari, Priyanka Rai, Amarjot Singh, Rohit Srivastava, Sunil Singh, Vaibhav Raj Gopal
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引用次数: 0

摘要

目的:乳房胀痛是女性的常见病,指乳房不适,可表现为周期性或非周期性。安抚、机械支持和各种非药物疗法(如亚麻籽)对治疗乳腺痛有良好效果。因此,本研究旨在调查亚麻籽对缓解乳腺增生相关疼痛的疗效及其对女性患者整体健康相关生活质量的影响:该研究在印度北部的一家三级医疗中心进行,历时 18 个月,采用单臂干预设计。参与者包括因乳房疼痛到普外科就诊的 18 岁及以上女性。干预措施包括每位受试者每天食用 30 克磨碎的亚麻籽,为期 6 个月。在补充亚麻籽之前和六个月的随访期间,使用视觉模拟量表(VAS)对疼痛的严重程度进行评估。同时,简表-12(SF-12)项目健康调查测量了与健康相关的生活质量,包括身体和心理健康领域。统计分析酌情采用参数检验(配对 t 检验)和非参数检验(秩和检验、McNemar 检验),统计显著性以 p 为限:200 名患有乳腺增生症的妇女接受了干预,其平均 VAS 分数从基线时的 6.03±0.83 显著降至干预后六个月时的 2.19±0.66(p = 0.0001)。疼痛强度的降低与补充亚麻籽的持续时间呈正相关,在最初的三个月后明显下降。首次就诊时和干预后 6 个月时,身体和精神 SF-12 评分的平均差异显著(p = 0.0001):这项研究强调了亚麻籽作为一种治疗选择的潜力,可用于控制乳腺增生并提高患者与健康相关的生活质量。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effect of Flaxseed on Pain Relief and Quality of Life in Patients With Mastalgia: A Single Arm Interventional Study.

Objective: Mastalgia, a common complaint among women, denotes breast discomfort that can manifest as cyclical or non-cyclical. Reassurance, mechanical support and various non-pharmacological treatments, like flaxseeds, have been seen to have a good effect in treating mastalgia. Thus, the aim of this study was to investigates the efficacy of flaxseed in alleviating pain associated with mastalgia and its impact on the overall health-related quality of life among female patients.

Materials and methods: Conducted at a tertiary care center in Northern India over 18 months, it employed a single-arm interventional design. The participants included females aged 18 years and older presenting with breast pain at the Department of General Surgery. The intervention involved daily consumption of 30 g of milled flaxseed for each participant, administered over a period of six months. Pain severity was assessed using the visual analogue scale (VAS) before supplementation and at follow-up intervals up to six months. Concurrently, the Short Form-12 (SF-12) items Health Survey measured health-related quality of life, encompassing both physical and mental health domains. Statistical analysis employed parametric (paired t-test) and non-parametric tests (chi-square, McNemar) where appropriate, with statistical significance set at p<0.05.

Results: Two hundred women with mastalgia were included with a significant reduction in mean VAS scores from 6.03±0.83 at baseline to 2.19±0.66 at six months post-intervention (p = 0.0001). This reduction in pain intensity demonstrated a positive correlation with duration of flaxseed supplementation, notably declining after the initial three months. The mean difference in physical and mental SF-12 score at first visit and at 6 months after intervention was significant (p = 0.0001).

Conclusion: This study underscores the potential of flaxseed as a therapeutic option for managing mastalgia and enhancing health-related quality of life among affected individuals.

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