配体激活的转录因子在 SERPINE 1 / PAI-1 基因调控的分子交响乐中的乐队。

IF 3.3 3区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biochimie Pub Date : 2025-01-01 DOI:10.1016/j.biochi.2024.09.010

Aneta Vrzalova, Radim Vrzal

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引用次数: 0

摘要

纤溶酶原激活物抑制剂 1（PAI-1）是一种重要的丝氨酸蛋白酶抑制剂，可通过抑制组织和尿激酶型纤溶酶原激活物（tPA、uPA）来防止纤溶酶原激活。PAI-1 因其分别通过抑制纤溶酶原或基质金属蛋白酶来调节血凝或细胞外基质的形成而闻名。PAI-1 由各种组织中的促炎细胞因子诱导，但配体激活转录因子对其的调控作用却部分被忽视。因此，我们试图总结目前关于与调节 PAI-1 水平有关的最相关的异生物和内分泌受体对 PAI-1 表达的转录调控的知识。这篇综述旨在帮助人们了解 PAI-1 的特异性调控，这种调控往往是组织依赖性的，并提供有关 PAI-1 水平调控的见解，而不仅仅是其直接抑制作用。

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Orchestra of ligand-activated transcription factors in the molecular symphony of SERPINE 1 / PAI-1 gene regulation

Plasminogen activator inhibitor 1 (PAI-1) is a crucial serine protease inhibitor that prevents plasminogen activation by inhibiting tissue- and urokinase-type plasminogen activators (tPA, uPA). PAI-1 is well-known for its role in modulating hemocoagulation or extracellular matrix formation by inhibiting plasmin or matrix metalloproteinases, respectively. PAI-1 is induced by pro-inflammatory cytokines across various tissues, yet its regulation by ligand-activated transcription factors is partly disregarded. Therefore, we have attempted to summarize the current knowledge on the transcriptional regulation of PAI-1 expression by the most relevant xenobiotic and endocrine receptors implicated in modulating PAI-1 levels. This review aims to contribute to the understanding of the specific, often tissue-dependent regulation of PAI-1 and provide insights into the modulation of PAI-1 levels beyond its direct inhibition.

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来源期刊

Biochimie 生物-生化与分子生物学

CiteScore

7.20

自引率

2.60%

发文量

219

审稿时长

40 days

期刊介绍： Biochimie publishes original research articles, short communications, review articles, graphical reviews, mini-reviews, and hypotheses in the broad areas of biology, including biochemistry, enzymology, molecular and cell biology, metabolic regulation, genetics, immunology, microbiology, structural biology, genomics, proteomics, and molecular mechanisms of disease. Biochimie publishes exclusively in English. Articles are subject to peer review, and must satisfy the requirements of originality, high scientific integrity and general interest to a broad range of readers. Submissions that are judged to be of sound scientific and technical quality but do not fully satisfy the requirements for publication in Biochimie may benefit from a transfer service to a more suitable journal within the same subject area.