肿瘤微环境中细胞外囊泡介导的串扰主导着肿瘤的命运。

IF 13 1区生物学 Q1 CELL BIOLOGY

Trends in Cell Biology Pub Date : 2024-09-25 DOI:10.1016/j.tcb.2024.08.008

Xinyu Dou, Chunyu Feng, Ji Li, Erhui Jiang, Zhengjun Shang

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引用次数: 0

摘要

肿瘤微环境（TME）是一个复杂的异构系统，包含各种相互合作和竞争的细胞。细胞外小泡（EVs）的形式和内容各不相同，是肿瘤微环境中重要的细胞间交流媒介。以往的研究主要关注的是 EVs 中的货物，而不是它们的来源和发挥其作用的受体细胞。因此，我们在此详细综述了 EVs 在塑造肿瘤命运方面的重要作用，并强调了它们在 TME 中的各种细胞间对话机制。我们评估了最近的研究进展，同时也提出了尚未解决的挑战，为使用 EVs 的临床治疗策略提供新思路。

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Extracellular vesicle-mediated crosstalk in tumor microenvironment dominates tumor fate.

The tumor microenvironment (TME) is a complex and heterogeneous system containing various cells cooperating and competing with each other. Extracellular vesicles (EVs) differing in form and content are important intercellular communication mediators in the TME. Previous studies have focused on the cargoes within EVs rather than on the donors from which they originate and the recipient cells that exert their effects. Therefore, we provide here a detailed overview of the important roles of EVs in shaping tumor fate, highlighting their various mechanisms of intercellular dialog within the TME. We evaluate recent advances and also raise unresolved challenges to provide new ideas for clinical treatment strategies using EVs.

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来源期刊

Trends in Cell Biology 生物-细胞生物学

CiteScore

32.00

自引率

0.50%

发文量

160

审稿时长

61 days

期刊介绍： Trends in Cell Biology stands as a prominent review journal in molecular and cell biology. Monthly review articles track the current breadth and depth of research in cell biology, reporting on emerging developments and integrating various methods, disciplines, and principles. Beyond Reviews, the journal features Opinion articles that follow trends, offer innovative ideas, and provide insights into the implications of new developments, suggesting future directions. All articles are commissioned from leading scientists and undergo rigorous peer-review to ensure balance and accuracy.