头颈部肉瘤:巴西一家三级转诊中心的三十年经验。

IF 2.3 3区 医学 Q1 OTORHINOLARYNGOLOGY
Marcelo Elias Schempf Cattan, Talita de Carvalho Kimura, Luccas Lavareze, Erika Said Abu Egal, Albina Altemani, Fernanda Viviane Mariano
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引用次数: 0

摘要

目的:本研究分析了在巴西一家三级参考中心确诊的头颈部肉瘤(HNS)的人口统计学、临床病理学、治疗和生存特征。对病历进行了检查,以提取人口统计学、临床病理学和随访信息。采用皮尔逊卡方检验、Kaplan-Meier曲线和Cox比例危险回归模型来确定存活率和潜在的预后因素:研究共纳入了 47 名患者。大多数患者为男性(61.7%),平均年龄为 38.9 岁。鼻腔(34.0%)是最常见的解剖部位。病变通常表现为体积增大(78.7%)。最常见的组织学亚型是软骨肉瘤、骨肉瘤和肺泡横纹肌肉瘤。单纯手术切除是最常见的治疗方式。10例患者出现局部复发,3例出现转移。从确诊到最后一次随访的平均随访时间为71.9个月,其中31名患者(65.9%)无病存活。在平均 14.3 个月的随访期内,共有 10 名患者(21.3%)死于 HNS。研究发现,发病时间超过 6 个月(p = 0.0309)和出现转移(p = 0.0315)是生存率的预后因素,而男性则是复发的独立预后因素:总之,本研究结果表明,病变出现时间较短和出现转移与 HNS 患者生存率降低有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Head and neck sarcomas: Thirty years of experience in a tertiary referral center in Brazil.

Purpose: This study analyzed the demographics, clinicopathological, treatment, and survival characteristics of head and neck sarcomas (HNS) diagnosed in a tertiary reference center in Brazil.

Materials and methods: HNS cases were retrospectively retrieved from the Department of Pathological Anatomy of the School of Medical Sciences of the State University of Campinas. The medical records were examined to extract demographic, clinicopathological, and follow-up information. The Pearson chi-square test, Kaplan-Meier curve, and Cox proportional hazards regression model were employed to identify survival and potential prognostic factors.

Results: A total of 47 patients were included in the study. The majority were men (61.7%) with a mean age of 38.9 years. The nasal cavity (34.0%) was the most common anatomical site. The lesions are usually presented as volume increases (78.7%). The most common histological subtypes were chondrosarcoma, osteosarcoma, and alveolar rhabdomyosarcoma. Surgical excision alone was the most common treatment modality. Local recurrence was observed in 10 cases, and metastases in 3 cases. During a mean follow-up period of 71.9 months, from diagnosis to the last follow-up, 31 patients (65.9%) were alive without the disease. A total of 10 patients (21.3%) died of the HNS for a mean follow-up period of 14.3 months. The time to presentation of more than 6 months (p = 0.0309) and the presence of metastases (p = 0.0315) were identified as prognostic factors for survival, while male sex was found to be an independent prognostic factor for recurrence.

Conclusion: In conclusion, the results of this study indicate that the occurrence of a shorter lesion time to presentation and the presence of metastases were associated with a reduction in survival rates in patients with HNS.

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来源期刊
CiteScore
7.00
自引率
6.90%
发文量
278
审稿时长
1.6 months
期刊介绍: Head & Neck is an international multidisciplinary publication of original contributions concerning the diagnosis and management of diseases of the head and neck. This area involves the overlapping interests and expertise of several surgical and medical specialties, including general surgery, neurosurgery, otolaryngology, plastic surgery, oral surgery, dermatology, ophthalmology, pathology, radiotherapy, medical oncology, and the corresponding basic sciences.
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