老年人脂肪组织炎症与体能的关系。

IF 5.2 2区 医学 Q1 GERIATRICS & GERONTOLOGY
Anna Tylutka, Barbara Morawin, Natalia Torz, Joanna Osmólska, Kacper Łuszczki, Paweł Jarmużek, Agnieszka Zembron-Lacny
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引用次数: 0

摘要

积极的生活方式对于减少肥胖、炎症和循环脂肪因子水平至关重要。因此,我们的研究旨在评估体能与慢性炎症状态之间的关系,并评估有助于分析脂肪组织功能障碍的生物标志物。根据步速值(1.4-1.8 米/秒或小于 1.3 米/秒),63 名老年人(69.6 ± 5.1 岁)被分配到高体能组 n = 31(女性 n = 23,男性 n = 8)或低体能组 n = 32(女性 n = 29,男性 n = 3)。步速与手握力(rs = 0.493,p = 0.0001)和瘦素水平(R = -0.372,p = 0.003)相关,这表明体育锻炼对肌肉力量和循环脂肪因子有好处。在低体能组中,58.1%的人的脂肪连通素与瘦素比率(Adpn/Lep)为 2。在高体能组中,25.8%的人的 Adpn/Lep ≥ 1.0,即在参考范围内。全身炎症指标与体能有明显关系:CRP/步速(rs = -0.377)和HMGB-1/步速(rs = -0.264)。Adpn(AUC = 0.526)、Lep(AUC = 0.745)和 HMGB-1(AUC = 0.689)的 ROC 分析结果表明,它们对老年患者的临床预后具有诊断潜力。Adpn 的最佳阈值为 1.2 μg/mL(灵敏度 74.2%,特异性 41.9%,OR = 1.4,95%Cl 0.488-3.902),Lep 为 6.7 ng/mL(灵敏度 56.2%,特异性 93.5%,OR = 14.8,95%Cl 3.574-112.229),CRP 2.63 mg/L(敏感性 51.6%,特异性 84.3%,OR = 4.4,95%Cl 1.401-16.063),HMGB-1 34.2 ng/mL(敏感性 62.0%,特异性 86.6%,OR = 12.0,95%Cl 3.254-61.614)。瘦素和 HMGB-1 的灵敏度和特异性最高。该研究揭示了不同体能水平的老年人炎症状态的变化,并证明了脂肪因子在评估脂肪组织炎症中的诊断作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Association of adipose tissue inflammation and physical fitness in older adults.

An active lifestyle is of key importance for reduction of obesity and inflammation, as well as circulating levels of adipokines. Therefore, the aim of our study was to assess the relationship of physical fitness with chronic inflammatory status, and to evaluate biomarkers useful in the analysis of adipose tissue dysfunction. Sixty-three older adults (69.6 ± 5.1 years) were allocated to a high n = 31 (women n = 23 and men n = 8 male) or low physical fitness n = 32 (women n = 29 and men n = 3) group based on gait speed values (1.4-1.8 m/s or ≤ 1.3 m/s). The gait speed correlated with hand grip strength (rs = 0.493, p = 0.0001) and with leptin level (R = -0.372, p = 0.003), which shows the benefits of physical activity on muscle strength and circulating adipokines. In low physical fitness group, 58.1% individuals had adiponectin to leptin ratio (Adpn/Lep) < 0.5 revealing dysfunction of adipose tissue and high cardiometabolic risk; 20% of the group were obese with BMI ≥ 30 kg/m2. In high physical fitness group, 25.8% of individuals had Adpn/Lep ≥ 1.0 i.e., within the reference range. Markers of systemic inflammation were significantly related to physical fitness: CRP/gait speed (rs = -0.377) and HMGB-1/gait speed (rs = -0.264). The results of the ROC analysis for Adpn (AUC = 0.526), Lep (AUC = 0.745) and HMGB-1 (AUC = 0.689) indicated their diagnostic potential for clinical prognosis in older patients. The optimal threshold values corresponded to 1.2 μg/mL for Adpn (sensitivity 74.2%, specificity 41.9%, OR = 1.4, 95%Cl 0.488-3.902), 6.7 ng/mL for Lep (sensitivity 56.2%, specificity 93.5%, OR = 14.8, 95%Cl 3.574-112.229), 2.63 mg/L for CRP (sensitivity 51.6%, specificity 84.3%, OR = 4.4, 95% Cl 1.401- 16.063) and 34.2 ng/mL for HMGB-1 (sensitivity 62.0%, specificity 86.6%, OR = 12.0, 95%Cl 3.254-61.614). The highest sensitivity and specificity were observed for Leptin and HMGB-1. The study revealed changes in inflammatory status in older adults at various levels of physical fitness and demonstrated diagnostic usefulness of adipokines in the assessment of adipose tissue inflammation.

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来源期刊
Immunity & Ageing
Immunity & Ageing GERIATRICS & GERONTOLOGY-IMMUNOLOGY
CiteScore
10.20
自引率
3.80%
发文量
55
期刊介绍: Immunity & Ageing is a specialist open access journal that was first published in 2004. The journal focuses on the impact of ageing on immune systems, the influence of aged immune systems on organismal well-being and longevity, age-associated diseases with immune etiology, and potential immune interventions to increase health span. All articles published in Immunity & Ageing are indexed in the following databases: Biological Abstracts, BIOSIS, CAS, Citebase, DOAJ, Embase, Google Scholar, Journal Citation Reports/Science Edition, OAIster, PubMed, PubMed Central, Science Citation Index Expanded, SCImago, Scopus, SOCOLAR, and Zetoc.
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