{"title":"海鲜和鱼油补充剂摄入量与持续性耳鸣风险的纵向研究。","authors":"Sharon G Curhan, Oana A Zeleznik, Gary C Curhan","doi":"10.1016/j.ajcnut.2024.09.028","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Persistent tinnitus is common, disabling, and difficult to treat. Diet has been implicated in tinnitus etiology, but studies are inconsistent and longitudinal data are scarce. Seafood intake is associated with lower risk of hearing loss, but the longitudinal association with tinnitus is unknown.</p><p><strong>Objective: </strong>We examined the independent associations of seafood intake, fish oil supplement use, and risk of developing persistent tinnitus.</p><p><strong>Methods: </strong>This prospective cohort study followed 73,482 females in the Nurses' Health Study II from 1991 to 2021. Diet was assessed using a validated food frequency questionnaire every 4 years. Multivariable-adjusted Cox proportional hazards regression was used to evaluate independent associations between total seafood intake, specific types of fish, shellfish, fish oil supplements, and risk of persistent tinnitus (defined as tinnitus experienced daily).</p><p><strong>Results: </strong>After 1,998,421 person-years of follow-up, 9,362 cases of incident persistent tinnitus were reported. Seafood intake was independently associated with lower risk of developing persistent tinnitus. Compared with participants who never or rarely consumed seafood, the multivariable-adjusted hazard ratios (MVHR,95% CI) for tinnitus were 0.87 (0.78, 0.95) among participants who consumed 1 serving/week, 0.77 (0.68, 0.86) for 2-4 servings/week, and 0.79 (0.64, 0.96) for 5+/servings/week (p-trend<0.0001). Examined individually, higher intakes of tuna fish, light-meat fish and shellfish were associated with lower risk. Compared with participants who never or rarely consumed the specific type, the MVHRs for consumption of 1+ servings/week were 0.84 (0.78, 0.90)(p-trend <0.0001) for tuna fish, 0.91 (0.83, 0.99)(p-trend=0.04) for light-meat fish, and 0.82 (0.72, 0.93)(p-trend<0.0001) for shellfish. Higher risk for dark-meat fish intake was suggested (MVHR: 1.09 (0.99,1.21)(p-trend=0.04). Fish oil supplement use (yes/no) was associated with higher risk (MVHR: 1.12 (1.06,1.19)).</p><p><strong>Conclusion: </strong>Regular consumption of tuna fish, light-meat fish or shellfish is associated with lower risk of developing persistent tinnitus in females. Fish oil supplement use is associated with higher risk.</p>","PeriodicalId":50813,"journal":{"name":"American Journal of Clinical Nutrition","volume":null,"pages":null},"PeriodicalIF":6.5000,"publicationDate":"2024-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Longitudinal Study of Seafood and Fish Oil Supplement Intake and Risk of Persistent Tinnitus.\",\"authors\":\"Sharon G Curhan, Oana A Zeleznik, Gary C Curhan\",\"doi\":\"10.1016/j.ajcnut.2024.09.028\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Persistent tinnitus is common, disabling, and difficult to treat. Diet has been implicated in tinnitus etiology, but studies are inconsistent and longitudinal data are scarce. Seafood intake is associated with lower risk of hearing loss, but the longitudinal association with tinnitus is unknown.</p><p><strong>Objective: </strong>We examined the independent associations of seafood intake, fish oil supplement use, and risk of developing persistent tinnitus.</p><p><strong>Methods: </strong>This prospective cohort study followed 73,482 females in the Nurses' Health Study II from 1991 to 2021. Diet was assessed using a validated food frequency questionnaire every 4 years. Multivariable-adjusted Cox proportional hazards regression was used to evaluate independent associations between total seafood intake, specific types of fish, shellfish, fish oil supplements, and risk of persistent tinnitus (defined as tinnitus experienced daily).</p><p><strong>Results: </strong>After 1,998,421 person-years of follow-up, 9,362 cases of incident persistent tinnitus were reported. Seafood intake was independently associated with lower risk of developing persistent tinnitus. Compared with participants who never or rarely consumed seafood, the multivariable-adjusted hazard ratios (MVHR,95% CI) for tinnitus were 0.87 (0.78, 0.95) among participants who consumed 1 serving/week, 0.77 (0.68, 0.86) for 2-4 servings/week, and 0.79 (0.64, 0.96) for 5+/servings/week (p-trend<0.0001). Examined individually, higher intakes of tuna fish, light-meat fish and shellfish were associated with lower risk. Compared with participants who never or rarely consumed the specific type, the MVHRs for consumption of 1+ servings/week were 0.84 (0.78, 0.90)(p-trend <0.0001) for tuna fish, 0.91 (0.83, 0.99)(p-trend=0.04) for light-meat fish, and 0.82 (0.72, 0.93)(p-trend<0.0001) for shellfish. Higher risk for dark-meat fish intake was suggested (MVHR: 1.09 (0.99,1.21)(p-trend=0.04). Fish oil supplement use (yes/no) was associated with higher risk (MVHR: 1.12 (1.06,1.19)).</p><p><strong>Conclusion: </strong>Regular consumption of tuna fish, light-meat fish or shellfish is associated with lower risk of developing persistent tinnitus in females. Fish oil supplement use is associated with higher risk.</p>\",\"PeriodicalId\":50813,\"journal\":{\"name\":\"American Journal of Clinical Nutrition\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":6.5000,\"publicationDate\":\"2024-09-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"American Journal of Clinical Nutrition\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1016/j.ajcnut.2024.09.028\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"NUTRITION & DIETETICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"American Journal of Clinical Nutrition","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.ajcnut.2024.09.028","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"NUTRITION & DIETETICS","Score":null,"Total":0}
Longitudinal Study of Seafood and Fish Oil Supplement Intake and Risk of Persistent Tinnitus.
Background: Persistent tinnitus is common, disabling, and difficult to treat. Diet has been implicated in tinnitus etiology, but studies are inconsistent and longitudinal data are scarce. Seafood intake is associated with lower risk of hearing loss, but the longitudinal association with tinnitus is unknown.
Objective: We examined the independent associations of seafood intake, fish oil supplement use, and risk of developing persistent tinnitus.
Methods: This prospective cohort study followed 73,482 females in the Nurses' Health Study II from 1991 to 2021. Diet was assessed using a validated food frequency questionnaire every 4 years. Multivariable-adjusted Cox proportional hazards regression was used to evaluate independent associations between total seafood intake, specific types of fish, shellfish, fish oil supplements, and risk of persistent tinnitus (defined as tinnitus experienced daily).
Results: After 1,998,421 person-years of follow-up, 9,362 cases of incident persistent tinnitus were reported. Seafood intake was independently associated with lower risk of developing persistent tinnitus. Compared with participants who never or rarely consumed seafood, the multivariable-adjusted hazard ratios (MVHR,95% CI) for tinnitus were 0.87 (0.78, 0.95) among participants who consumed 1 serving/week, 0.77 (0.68, 0.86) for 2-4 servings/week, and 0.79 (0.64, 0.96) for 5+/servings/week (p-trend<0.0001). Examined individually, higher intakes of tuna fish, light-meat fish and shellfish were associated with lower risk. Compared with participants who never or rarely consumed the specific type, the MVHRs for consumption of 1+ servings/week were 0.84 (0.78, 0.90)(p-trend <0.0001) for tuna fish, 0.91 (0.83, 0.99)(p-trend=0.04) for light-meat fish, and 0.82 (0.72, 0.93)(p-trend<0.0001) for shellfish. Higher risk for dark-meat fish intake was suggested (MVHR: 1.09 (0.99,1.21)(p-trend=0.04). Fish oil supplement use (yes/no) was associated with higher risk (MVHR: 1.12 (1.06,1.19)).
Conclusion: Regular consumption of tuna fish, light-meat fish or shellfish is associated with lower risk of developing persistent tinnitus in females. Fish oil supplement use is associated with higher risk.
期刊介绍:
American Journal of Clinical Nutrition is recognized as the most highly rated peer-reviewed, primary research journal in nutrition and dietetics.It focuses on publishing the latest research on various topics in nutrition, including but not limited to obesity, vitamins and minerals, nutrition and disease, and energy metabolism.
Purpose:
The purpose of AJCN is to:
Publish original research studies relevant to human and clinical nutrition.
Consider well-controlled clinical studies describing scientific mechanisms, efficacy, and safety of dietary interventions in the context of disease prevention or health benefits.
Encourage public health and epidemiologic studies relevant to human nutrition.
Promote innovative investigations of nutritional questions employing epigenetic, genomic, proteomic, and metabolomic approaches.
Include solicited editorials, book reviews, solicited or unsolicited review articles, invited controversy position papers, and letters to the Editor related to prior AJCN articles.
Peer Review Process:
All submitted material with scientific content undergoes peer review by the Editors or their designees before acceptance for publication.