电刺激治疗收缩功能减退的膀胱

IF 12.1 1区医学 Q1 UROLOGY & NEPHROLOGY

Nature Reviews Urology Pub Date : 2024-09-30 DOI:10.1038/s41585-024-00949-w

Nima Nassiri, Lauren Schafrank, Michael Chen, Madeleine Burg, Victor Nitti

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引用次数: 0

摘要

由于人口老龄化和糖尿病发病率的增加，预计逼尿肌活动不足的发病率将上升，但治疗方案仍然有限。在动物膀胱起搏研究中，膀胱收缩取得了成功。然而，解剖学上的不协调凸显了人体试验的必要性。通过电刺激对人体进行膀胱起搏已显示出一定的潜力，但由于在试验过程中存在逼尿肌-括约肌协同障碍和患者不适，因此缺乏可持续的方案。因此，对脑死亡患者进行测压研究可作为开发植入式膀胱起搏装置以恢复收缩力的模型。

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Electrical stimulation for the hypocontractile bladder

The incidence of detrusor underactivity is projected to rise owing to an ageing population and the increasing prevalence of diabetes, but therapeutic options remain limited. Successful bladder contractions have been yielded in studies of bladder pacing in animals. However, anatomical incongruities highlight the need for human trials. Bladder pacing in humans through electrical stimulation has shown some potential, although sustainable protocols are lacking owing to detrusor–sphincter dyssynergia and patient discomfort during trials. Thus, manometric studies in brain-dead patients might serve as a model for developing an implantable bladder pacing device to restore contractility.

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来源期刊

Nature Reviews Urology 医学-泌尿学与肾脏学

CiteScore

12.50

自引率

2.60%

发文量

123

审稿时长

6-12 weeks

期刊介绍： Nature Reviews Urology is part of the Nature Reviews portfolio of journals.Nature Reviews' basic, translational and clinical content is written by internationally renowned basic and clinical academics and researchers. This journal targeted readers in the biological and medical sciences, from the postgraduate level upwards, aiming to be accessible to professionals in any biological or medical discipline. The journal features authoritative In-depth Reviews providing up-to-date information on topics within a field's history and development. Perspectives, News & Views articles, and the Research Highlights section offer topical discussions and opinions, filtering primary research from various medical journals. Covering a wide range of subjects, including andrology, urologic oncology, and imaging, Nature Reviews provides valuable insights for practitioners, researchers, and academics within urology and related fields.