Ananda Cristina Fernandes de Aguiar, Nancy Cristina Ferraz de Lucena Ferreira, Maria Amelia Carlos Souto Maior Borba, Darley de Lima Ferreira Filho, Glauber Moreira Leitão, Luiz Alberto Mattos, José Luiz de Lima Filho, Danyelly Bruneska Gondim Martins
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引用次数: 0
摘要
受体酪氨酸激酶（RTKs）参与细胞的生长、运动和分化。RTKs信号的失调与肿瘤的发展和耐药性有关。TAM（TYRO3、AXL、MERTK）、RON、EPH和MET等潜在的RTKs已在肺癌、前列腺癌和结直肠癌等多种癌症中进行了评估，但对乳腺肿瘤却知之甚少。本研究通过 qPCR 评估了 51 个腔隙性乳腺癌组织和 8 个三阴性乳腺癌（TNBC）亚型中 TAM、RON、EPHA2 和 MET 基因的表达情况。进行了统计分析以确定与临床数据的相关性。TYRO3与肿瘤亚型和分期、患者年龄、吸烟习惯和肥胖有关。MET 的表达与 EPHA2 和 TAM 基因的表达相关。EPHA2 的表达还与年龄和吸烟习惯有关。TAM和EPHA2基因的表达水平似乎在乳腺癌中起着重要作用，同时也受患者生活方式的影响。
TYRO3 and EPHA2 Expression Are Dysregulated in Breast Cancer
Receptor tyrosine kinases (RTKs) are involved in cell growth, motility, and differentiation. Deregulation of RTKs signaling is associated with tumor development and therapy resistance. Potential RTKs like TAM (TYRO3, AXL, MERTK), RON, EPH, and MET have been evaluated in many cancers like lung, prostate, and colorectal, but little is known in breast tumors. In this study, 51 luminal breast cancer tissue and 8 triple negative breast cancer (TNBC) subtypes were evaluated by qPCR for the expression of TAM, RON, EPHA2, and MET genes. Statistical analysis was performed to determine the correlation to clinical data. TYRO3 is related to tumor subtype and stage, patient's age, smoking habits, and obesity. MET expression is correlated to EPHA2 and TAM gene expression. EPHA2 expression is also related to aging and smoking habits. The expression levels of the TAM and EPHA2 genes seem to play an important role in breast cancer, being also influenced by the patient's lifestyle.
期刊介绍：
Cell Biochemistry and Function publishes original research articles and reviews on the mechanisms whereby molecular and biochemical processes control cellular activity with a particular emphasis on the integration of molecular and cell biology, biochemistry and physiology in the regulation of tissue function in health and disease.
The primary remit of the journal is on mammalian biology both in vivo and in vitro but studies of cells in situ are especially encouraged. Observational and pathological studies will be considered providing they include a rational discussion of the possible molecular and biochemical mechanisms behind them and the immediate impact of these observations to our understanding of mammalian biology.
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