冬季出生：瑞士早期精神病队列中功能不良的一个因素

IF 3.6 2区医学 Q1 PSYCHIATRY

Schizophrenia Research Pub Date : 2024-09-27 DOI:10.1016/j.schres.2024.09.022

Romeo Restellini , Philippe Golay , Raoul Jenni , Philipp S. Baumann , Luis Alameda , Larissa Allgäuer , Pascal Steullet , Lilith Abrahamyan Empson , Nadir Mebdouhi , Kim Quang Do , Philippe Conus , Daniella Dwir , Paul Klauser

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引用次数: 0

摘要

目的冬季出生一直被认为是精神分裂症的一个危险因素。本研究旨在确定在这个季节出生的人是否也有更高的早期精神病风险，以及这是否与不同的功能和临床结果有关。方法我们对瑞士 222 名处于精神病早期阶段的患者进行了一项前瞻性研究，这些患者嵌套在精神病治疗和早期干预（TIPP）队列中。我们将这些患者的出生三个月与瑞士普通人群的出生三个月进行了比较。此外，在为期三年的随访期间，我们还评估了冬季（1 月至 3 月）出生的患者与其他时间出生的患者的全球功能评估量表（GAF）和阳性与阴性综合征量表（PANSS）得分。与其他季节出生的患者相比，冬季出生的患者在6个月、24个月和36个月的随访中GAF评分明显较低。结论：冬季出生的患者似乎与较低的功能预后和早期精神病的潜在症状有关。

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Winter birth: A factor of poor functional outcome in a Swiss early psychosis cohort

Objective

Winter birth has consistently been identified as a risk factor for schizophrenia. This study aimed to determine whether individuals born during this season are also at higher risk for early psychosis and whether this is associated with distinct functional and clinical outcomes.

Methods

We conducted a prospective study on 222 patients during their early phase of psychosis in Switzerland, nested in the Treatment and Early Intervention in Psychosis (TIPP) cohort. We compared the birth trimesters of these patients with those of the general Swiss population. Additionally, we evaluated the Global Assessment of Functioning scale (GAF) and the Positive and Negative Syndrome Scale (PANSS) scores among patients born in winter (January to March) versus those born during the rest of the year during a three-year follow-up period.

Results

A significantly higher proportion of patients experiencing early psychosis were born in winter compared to the general Swiss population. Patients born in winter had significantly lower GAF scores at 6 months, 24 months, and 36 months of follow-up, compared to patients born during the rest of the year. They also manifested fewer positive symptoms, as indicated by the PANSS positive subscale.

Conclusion

Birth in winter appears to be associated with a lower functional outcome and potentially distinct symptomatology in the early phase of psychosis.

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来源期刊

Schizophrenia Research 医学-精神病学

CiteScore

7.50

自引率

8.90%

发文量

429

审稿时长

10.2 weeks

期刊介绍： As official journal of the Schizophrenia International Research Society (SIRS) Schizophrenia Research is THE journal of choice for international researchers and clinicians to share their work with the global schizophrenia research community. More than 6000 institutes have online or print (or both) access to this journal - the largest specialist journal in the field, with the largest readership! Schizophrenia Research''s time to first decision is as fast as 6 weeks and its publishing speed is as fast as 4 weeks until online publication (corrected proof/Article in Press) after acceptance and 14 weeks from acceptance until publication in a printed issue. The journal publishes novel papers that really contribute to understanding the biology and treatment of schizophrenic disorders; Schizophrenia Research brings together biological, clinical and psychological research in order to stimulate the synthesis of findings from all disciplines involved in improving patient outcomes in schizophrenia.