慢性阻塞性肺病评估测试对纤维化间质性肺病的反应性和最小临床重要差异

IF 2.4 Q2 RESPIRATORY SYSTEM

Respiratory investigation Pub Date : 2024-09-26 DOI:10.1016/j.resinv.2024.08.006

Toshiaki Matsuda , Yasuhiro Kondoh , Reoto Takei , Hajime Sasano , Jun Fukihara , Yasuhiko Yamano , Toshiki Yokoyama , Kensuke Kataoka , Fumiko Watanabe , Tomoki Kimura

{"title":"慢性阻塞性肺病评估测试对纤维化间质性肺病的反应性和最小临床重要差异","authors":"Toshiaki Matsuda , Yasuhiro Kondoh , Reoto Takei , Hajime Sasano , Jun Fukihara , Yasuhiko Yamano , Toshiki Yokoyama , Kensuke Kataoka , Fumiko Watanabe , Tomoki Kimura","doi":"10.1016/j.resinv.2024.08.006","DOIUrl":null,"url":null,"abstract":"<div><h3>Background and objective</h3><div>Patients with fibrotic interstitial lung disease (FILD) have impaired health status. The simple questionnaire in the COPD assessment test (CAT) has been validated for idiopathic pulmonary fibrosis (IPF) and connective tissue disease-related interstitial lung disease (CTD-ILD), but no or limited data exist for patients with FILD as a whole. The aim of this study was to evaluate the reliability, repeatability and responsiveness of the CAT, and estimate the minimal clinically important difference (MCID) in patients with FILD.</div></div><div><h3>Methods</h3><div>This study was a retrospective chart review of 358 consecutive patients with FILD including 131 with IPF, who underwent clinical assessment over 6–12 month intervals. We assessed the cross-sectional and longitudinal validity of the CAT. MCID was estimated using distribution methods and anchor methods with mean change and regression models.</div></div><div><h3>Results</h3><div>Internal consistency (Cronbach's alpha = 0.898) and repeatability (intraclass correlation coefficient [ICC] = 0.865) for the CAT score was acceptable. A cross-sectional study showed constructive validity. Changes in the CAT over 6–12 months were significantly associated with change in anchors including physiological function, exercise capacity, and dyspnea regardless of IPF diagnosis. The estimated MCIDs of the CAT for the deterioration and improvement directions were at least +5 and at least −3 points, respectively.</div></div><div><h3>Conclusions</h3><div>The CAT is a reliable, responsive and clinically relevant instrument for assessing health status in patients with FILD.</div></div>","PeriodicalId":20934,"journal":{"name":"Respiratory investigation","volume":"62 6","pages":"Pages 1088-1093"},"PeriodicalIF":2.4000,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Responsiveness and minimal clinically important difference of the COPD Assessment Test in fibrotic interstitial lung disease\",\"authors\":\"Toshiaki Matsuda , Yasuhiro Kondoh , Reoto Takei , Hajime Sasano , Jun Fukihara , Yasuhiko Yamano , Toshiki Yokoyama , Kensuke Kataoka , Fumiko Watanabe , Tomoki Kimura\",\"doi\":\"10.1016/j.resinv.2024.08.006\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background and objective</h3><div>Patients with fibrotic interstitial lung disease (FILD) have impaired health status. The simple questionnaire in the COPD assessment test (CAT) has been validated for idiopathic pulmonary fibrosis (IPF) and connective tissue disease-related interstitial lung disease (CTD-ILD), but no or limited data exist for patients with FILD as a whole. The aim of this study was to evaluate the reliability, repeatability and responsiveness of the CAT, and estimate the minimal clinically important difference (MCID) in patients with FILD.</div></div><div><h3>Methods</h3><div>This study was a retrospective chart review of 358 consecutive patients with FILD including 131 with IPF, who underwent clinical assessment over 6–12 month intervals. We assessed the cross-sectional and longitudinal validity of the CAT. MCID was estimated using distribution methods and anchor methods with mean change and regression models.</div></div><div><h3>Results</h3><div>Internal consistency (Cronbach's alpha = 0.898) and repeatability (intraclass correlation coefficient [ICC] = 0.865) for the CAT score was acceptable. A cross-sectional study showed constructive validity. Changes in the CAT over 6–12 months were significantly associated with change in anchors including physiological function, exercise capacity, and dyspnea regardless of IPF diagnosis. The estimated MCIDs of the CAT for the deterioration and improvement directions were at least +5 and at least −3 points, respectively.</div></div><div><h3>Conclusions</h3><div>The CAT is a reliable, responsive and clinically relevant instrument for assessing health status in patients with FILD.</div></div>\",\"PeriodicalId\":20934,\"journal\":{\"name\":\"Respiratory investigation\",\"volume\":\"62 6\",\"pages\":\"Pages 1088-1093\"},\"PeriodicalIF\":2.4000,\"publicationDate\":\"2024-09-26\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Respiratory investigation\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2212534524001278\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"RESPIRATORY SYSTEM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Respiratory investigation","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2212534524001278","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"RESPIRATORY SYSTEM","Score":null,"Total":0}

引用次数: 0

摘要

背景和目的纤维化间质性肺病（FILD）患者的健康状况受损。慢性阻塞性肺病评估测试（COPD assessment test，CAT）中的简易问卷已针对特发性肺纤维化（IPF）和结缔组织病相关间质性肺病（CTD-ILD）进行了验证，但没有关于整个纤维化间质性肺病患者的数据或数据有限。本研究的目的是评估 CAT 的可靠性、可重复性和响应性，并估算 FILD 患者的最小临床重要差异 (MCID)。我们评估了 CAT 的横向和纵向有效性。结果CAT评分的内部一致性（Cronbach's alpha = 0.898）和可重复性（类内相关系数 [ICC] = 0.865）均可接受。一项横断面研究显示了建设性有效性。无论 IPF 诊断与否，CAT 在 6-12 个月内的变化与生理功能、运动能力和呼吸困难等锚点的变化有显著相关性。结论 CAT 是一种可靠、反应灵敏且与临床相关的工具，可用于评估 FILD 患者的健康状况。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Responsiveness and minimal clinically important difference of the COPD Assessment Test in fibrotic interstitial lung disease

Background and objective

Patients with fibrotic interstitial lung disease (FILD) have impaired health status. The simple questionnaire in the COPD assessment test (CAT) has been validated for idiopathic pulmonary fibrosis (IPF) and connective tissue disease-related interstitial lung disease (CTD-ILD), but no or limited data exist for patients with FILD as a whole. The aim of this study was to evaluate the reliability, repeatability and responsiveness of the CAT, and estimate the minimal clinically important difference (MCID) in patients with FILD.

Methods

This study was a retrospective chart review of 358 consecutive patients with FILD including 131 with IPF, who underwent clinical assessment over 6–12 month intervals. We assessed the cross-sectional and longitudinal validity of the CAT. MCID was estimated using distribution methods and anchor methods with mean change and regression models.

Results

Internal consistency (Cronbach's alpha = 0.898) and repeatability (intraclass correlation coefficient [ICC] = 0.865) for the CAT score was acceptable. A cross-sectional study showed constructive validity. Changes in the CAT over 6–12 months were significantly associated with change in anchors including physiological function, exercise capacity, and dyspnea regardless of IPF diagnosis. The estimated MCIDs of the CAT for the deterioration and improvement directions were at least +5 and at least −3 points, respectively.