阻力运动对改善甲基苯丙胺使用障碍者的渴求和执行功能的剂量反应效应

IF 2.3 3区医学 Q2 PSYCHIATRY

Mental Health and Physical Activity Pub Date : 2024-09-18 DOI:10.1016/j.mhpa.2024.100633

Jianjing Jin , Xiaohui Zhai , Adrian Taylor , Ting Zhu , Dongshi Wang , Bo Peng , Ke Wang

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引用次数: 0

摘要

目的抵抗运动（RE）可迅速改善甲基苯丙胺使用障碍（MUD）患者的症状，但最佳剂量尚未确定。方法将128名男性MUD参与者（34.73 ± 5.65）随机分配到低强度（30%-35%1-RM）RE组（LREG）、中等强度（55%-60%1-RM）RE组（MREG）、高强度（75%-80%1-RM）RE组（HREG）或对照组（CONG）。在急性 RE 之前、之后和之后 40 分钟测量了基于线索反应范式的渴求度，并在急性 RE 之前和之后测量了抑制控制、工作记忆和认知灵活性。趋势分析显示，RE强度和Δ线索诱发的渴求度呈U形剂量反应曲线，表明中等强度的RE对线索诱发的渴求度具有最大的改善作用。Δ抑制控制和Δ工作记忆得分仅在MREG中有所提高，而Δ认知灵活性得分在所有RE组中都有显著提高。趋势分析表明，RE 强度与抑制控制之间存在立方曲线关系，与工作记忆和认知灵活性之间存在二次曲线关系。RE 强度、线索诱发的渴求和执行功能之间存在明显的剂量-反应关系，中等强度的 RE 对 MUD 患者有更明显的改善作用。

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Dose‒response effects of resistance exercise on ameliorating cravings and executive functions in individuals with methamphetamine use disorders

Purpose

Resistance exercise (RE) can acutely benefit symptoms in individuals with methamphetamine use disorder (MUD), though the optimal dose has not yet been established. We aimed to determine the dose response relationship between RE intensity and cue-elicited cravings and executive functions in individuals with MUD.

Methods

A total of 128 male participants with MUD (34.73 ± 5.65) were randomly assigned to the low-intensity (30%–35%1-RM) RE group (LREG), moderate-intensity (55%–60%1-RM) RE group (MREG), high-intensity (75%–80%1-RM) RE group (HREG), or control group (CONG). Cravings based on the cue-reactivity paradigm were measured before, immediately after, and 40 min after acute RE, and inhibitory control, working memory, and cognitive flexibility were measured before and after acute RE.

Results

Immediately after and 40 min after RE, the Δcue-elicited cravings of the MREG from baseline was significantly more negative than that of the LREG and CONG. Trend analyses revealed a U-shaped dose‒response curve for RE intensity and Δcue-elicited cravings, indicating that moderate-intensity RE had the greatest ameliorating effect on cue-elicited cravings. Δinhibitory control and Δworking memory scores increased only in the MREG, and Δcognitive flexibility scores significantly increased in all RE groups. Trend analyses revealed a cubic curvilinear relationship between RE intensity and inhibitory control and a quadratic curvilinear relationship with working memory and cognitive flexibility.

Conclusion

RE proved effective in diminishing cue-elicited cravings and enhancing executive functions. A significant dose‒response relationship existed among RE intensity, cue-elicited cravings and executive function, and moderate-intensity RE had a more pronounced ameliorative effect on individuals with MUD.

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来源期刊

Mental Health and Physical Activity PSYCHIATRY-

CiteScore

6.70

自引率

6.40%

发文量

审稿时长

32 days

期刊介绍： The aims of Mental Health and Physical Activity will be: (1) to foster the inter-disciplinary development and understanding of the mental health and physical activity field; (2) to develop research designs and methods to advance our understanding; (3) to promote the publication of high quality research on the effects of physical activity (interventions and a single session) on a wide range of dimensions of mental health and psychological well-being (eg, depression, anxiety and stress responses, mood, cognitive functioning and neurological disorders, such as dementia, self-esteem and related constructs, psychological aspects of quality of life among people with physical and mental illness, sleep, addictive disorders, eating disorders), from both efficacy and effectiveness trials;