含硒葡萄籽和果皮提取物对赭曲霉毒素-A 暴露的雄性 Wistar 大鼠肾功能障碍的改善作用

IF 3.7 3区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Journal of King Saud University - Science Pub Date : 2024-09-17 DOI:10.1016/j.jksus.2024.103453

Mohamed Farouk Elsadek , Tse-Wei Chen , Khalid S. Al-Numair , Tasneem Sobhy Fahmy

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引用次数: 0

摘要

背景和目的药物诱导的肾毒性被广泛认为是肾脏疾病的初始阶段，尤其会导致急性肾损伤和慢性肾功能障碍。本研究探讨了葡萄皮提取物（GPE）、葡萄籽提取物（GSE）和硒（Sel）对控制赭曲霉毒素-A（OTA）诱导的雄性大鼠肾损伤的单一和联合作用。方法给 49 只体重为 200 ± 10 克的雄性 Wistar 大鼠注射 OTA（0.5 毫克/千克体重）以诱导肾毒性，然后用 GSE、GPE 和 Sel 的单一和联合应用进行治疗。此外，还对 OTA 诱导的肾毒性大鼠进行了各种生物和生理指标的筛查，如食物摄入量、体重增加、肝脏重量、血清肾脏生物标志物、血清脂质组分、酶和非酶脂质过氧化指标以及组织病理学研究。结果我们的研究结果表明，GSE 2 % 和硒（50-50）联合治疗可显著降低脂质过氧化指标、血脂和肾脏概况，增强酶和非酶抗氧化剂生物标志物，从而减轻 OTA 诱导的大鼠肾功能障碍，其次是 GSE 2 % 和硒（0.4 mg/kg）。对肾脏的组织学分析表明，OTA 诱导的大鼠肾小管退化更为严重，而 GSE 和 GPE 组合只显示出中度的肾小球簇扩大和轻微的肾小管退化。结论葡萄籽提取物和硒可用作膳食补充剂，以减少由化学物质或导致肾毒性的化合物引起的肾毒性。

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Ameliorating Effect of Grape (Vitis vinifera L.) Seed and Peel Extracts with Selenium on Ochratoxin-A Exposed Renal Dysfunction in Male Wistar Rats

Background and Aim

Drug-induced nephrotoxicity is extensively documented as the initial stage of kidney disease that particularly results in acute renal injury and chronic renal dysfunction. The single and combined effect of grape peel extract (GPE), grape seed extracts (GSE) and selenium (Sel) were investigated in current study for controlling of renal injury induced by Ochratoxin-A (OTA) in male rats.

Methods

Forty nine male Wistar rats weighing 200 ± 10 g were injected with OTA (0.5 mg/kg bw) to induce nephrotoxicity, then treated with singleand combined applications of GSE, GPE and Sel. In addition, the OTA induced nephrotoxicity rats were screened for various biological and physiological parameters like food ingestion, body weight gain, liver weight, serum kidney biomarkers, serum lipid fractions, enzymatic and non-enzymatic lipid peroxidation indicators and histopathological studies.

Results

Our findings suggested that the combination of GSE 2 % and Sel (50–50) treatment reduced renal dysfunction in OTA-induced rats by significantly lowering lipid peroxidation indicators, lipid and kidneys profiles and enhancing enzymatic and non-enzymatic antioxidants biomarkers followed by GSE 2 % then Selenium (0.4 mg/kg) in OTA. Histological analysis of the kidney revealed more severe renal tubule degeneration in OTA-induced rats, While GSE and GPE combonation showed only moderate glomerular tuft enlargement and minimal renal tubule deterioration. Furthermore, the combination of GSE 2 %+Sel (50–50) revealed normal histological structure.

Conclusions

Grape seed extracts along with selenium mightbe used as dietary supplements to reduce renal toxicity induced by chemicals or compounds that cause nephrotoxicity.

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来源期刊

Journal of King Saud University - Science Multidisciplinary-Multidisciplinary

CiteScore

7.20

自引率

2.60%

发文量

642

审稿时长

49 days

期刊介绍： Journal of King Saud University – Science is an official refereed publication of King Saud University and the publishing services is provided by Elsevier. It publishes peer-reviewed research articles in the fields of physics, astronomy, mathematics, statistics, chemistry, biochemistry, earth sciences, life and environmental sciences on the basis of scientific originality and interdisciplinary interest. It is devoted primarily to research papers but short communications, reviews and book reviews are also included. The editorial board and associated editors, composed of prominent scientists from around the world, are representative of the disciplines covered by the journal.