循环微RNA是异体造血干细胞移植后急性移植物抗宿主疾病诊断和预后的致命弱点

IF 1 Q4 GENETICS & HEREDITY

Gene Reports Pub Date : 2024-09-19 DOI:10.1016/j.genrep.2024.102037

Marzieh Izadifard , Mohammad Ahmadvand , Kamran Alimoghadam , Hossein Pashaiefar , Ghazal Seghatoleslami , Maryam Barkhordar , Marjan Yaghmaie

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引用次数: 0

摘要

急性移植物抗宿主疾病（aGVHD）是异基因造血干细胞移植（allo-HSCT）后常见的并发症，这种手术旨在治疗恶性和非恶性血液病。目前，还没有任何实验室检测方法可以准确预测罹患异基因造血干细胞抗宿主疾病的可能性、患者对治疗的反应或存活机会。令人鼓舞的是，特定的 microRNA 通过其失调的表达模式与 aGVHD 的发病、严重程度和临床后果有着一致的联系，为患者管理和个体化治疗计划提供了潜在的优势。此外，利用 qPCR、微阵列分析和新一代测序等高通量筛选技术对血液或尿液等体液中作为生物标志物的循环 microRNA 进行鉴定和测量，可使微创诊断方法变得更加简便。在诊断、预后和治疗反应方面，本综述集中于最新的研究，这些研究证明了血液和其他体液中的循环 microRNA 可作为 aGVHD 的微创生物标志物。microRNA 除了是改善 aGVHD 管理和患者预后的有用工具外，其在疾病生物学中独特的表达模式和功能也为个性化医疗带来了前景。

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Circulating microRNAs as the achilles forte of diagnostics and prognostics in acute graft versus host disease following allogeneic hematopoietic stem cell transplantation

Acute graft-versus-host disease (aGVHD) is a common complication after allogeneic hematopoietic stem cell transplantation (allo-HSCT), a procedure intended to treat malignant and nonmalignant hematological illnesses. At this time, there are no laboratory tests that can accurately forecast the likelihood of developing aGVHD, a patient's response to treatment, or their chance of life. Encouragingly, specific microRNAs have demonstrated consistent connections with the onset, severity, and clinical consequences of aGVHD through their dysregulated expression patterns, providing potential advantages in patient management and individualized therapy plans. Additionally, minimally invasive diagnostic methods are made easier by identification and measurement of circulating microRNAs as biomarkers in bodily fluids such as blood or urine using high-throughput screening techniques like qPCR, microarray analysis, and next-generation sequencing. Regarding the diagnosis, prognosis, and therapeutic response, this review is concentrated on the most recent research that offer proof of the possible utility of circulating microRNAs in blood and other bodily fluids as minimally invasive biomarkers of aGVHD. In addition to being useful tools for enhancing aGVHD management and patient outcomes, microRNAs distinctive expression patterns and functions in disease biology also present prospects for personalized medicine.

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来源期刊

Gene Reports Biochemistry, Genetics and Molecular Biology-Genetics

CiteScore

3.30

自引率

7.70%

发文量

246

审稿时长

49 days

期刊介绍： Gene Reports publishes papers that focus on the regulation, expression, function and evolution of genes in all biological contexts, including all prokaryotic and eukaryotic organisms, as well as viruses. Gene Reports strives to be a very diverse journal and topics in all fields will be considered for publication. Although not limited to the following, some general topics include: DNA Organization, Replication & Evolution -Focus on genomic DNA (chromosomal organization, comparative genomics, DNA replication, DNA repair, mobile DNA, mitochondrial DNA, chloroplast DNA). Expression & Function - Focus on functional RNAs (microRNAs, tRNAs, rRNAs, mRNA splicing, alternative polyadenylation) Regulation - Focus on processes that mediate gene-read out (epigenetics, chromatin, histone code, transcription, translation, protein degradation). Cell Signaling - Focus on mechanisms that control information flow into the nucleus to control gene expression (kinase and phosphatase pathways controlled by extra-cellular ligands, Wnt, Notch, TGFbeta/BMPs, FGFs, IGFs etc.) Profiling of gene expression and genetic variation - Focus on high throughput approaches (e.g., DeepSeq, ChIP-Seq, Affymetrix microarrays, proteomics) that define gene regulatory circuitry, molecular pathways and protein/protein networks. Genetics - Focus on development in model organisms (e.g., mouse, frog, fruit fly, worm), human genetic variation, population genetics, as well as agricultural and veterinary genetics. Molecular Pathology & Regenerative Medicine - Focus on the deregulation of molecular processes in human diseases and mechanisms supporting regeneration of tissues through pluripotent or multipotent stem cells.