纳米姜黄素抗癌和抗感染的改良新方法

IF 5.45 Q1 Physics and Astronomy

Nano-Structures & Nano-Objects Pub Date : 2024-09-26 DOI:10.1016/j.nanoso.2024.101352

Kokkarachedu Varaprasad , Natarajan Sisubalan , Tippabattini Jayaramudu , Murali M. Yallapu

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引用次数: 0

摘要

姜黄素的纳米制剂因其比传统姜黄素制剂更强的特性而备受关注，成为各种健康应用的一种有前途的替代品。姜黄素是从姜黄中提取的一种多酚有机抗氧化植物化学物质，具有广泛的治疗功效，但也面临着溶解度和生物利用度有限等挑战。基于姜黄素的纳米制剂具有更好的溶解性、稳定性和生物利用度，使其成为药物输送系统和靶向治疗的有益选择。最近的研究表明，纳米姜黄素对细菌感染有很好的抑制作用，其中包括耐多药菌株。此外，纳米姜黄素及其制剂通过有效抑制癌细胞和调节关键转录因子，在癌症治疗中大有可为。本综述总结了纳米姜黄素制剂的最新发展及其在癌症治疗和抗菌应用中的潜力，强调了其作为各种健康问题创新解决方案的作用。

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Nanocurcumin: A new and improved way to fight cancer and infections

Nanoformulations of curcumin have garnered significant attention as a promising alternative for various health applications due to their enhanced properties over conventional curcumin formulations. Curcumin, a polyphenol organic antioxidant phytochemical extracted from turmeric, exhibits a wide range of therapeutic benefits but faces challenges such as limited solubility and bioavailability. Curcumin-based nanoformulations offer improved solubility, stability, and bioavailability, driving them a beneficial option for pharmaceutical delivery systems and targeted therapies. Recent studies have highlighted nanocurcumin as superior bacterial infections and have included multidrug-resistant strains. Moreover, nanocurcumin and its formulations show promise in cancer treatment by effectively inhibiting cancer cells and regulating key transcription factors. This review summarizes recent developments in nanocurcumin formulations and their potential in cancer therapy and antibacterial applications, emphasizing their role as innovative solutions for various health issues.

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来源期刊

Nano-Structures & Nano-Objects Physics and Astronomy-Condensed Matter Physics

CiteScore

9.20

自引率

0.00%

发文量

审稿时长

22 days

期刊介绍： Nano-Structures & Nano-Objects is a new journal devoted to all aspects of the synthesis and the properties of this new flourishing domain. The journal is devoted to novel architectures at the nano-level with an emphasis on new synthesis and characterization methods. The journal is focused on the objects rather than on their applications. However, the research for new applications of original nano-structures & nano-objects in various fields such as nano-electronics, energy conversion, catalysis, drug delivery and nano-medicine is also welcome. The scope of Nano-Structures & Nano-Objects involves: -Metal and alloy nanoparticles with complex nanostructures such as shape control, core-shell and dumbells -Oxide nanoparticles and nanostructures, with complex oxide/metal, oxide/surface and oxide /organic interfaces -Inorganic semi-conducting nanoparticles (quantum dots) with an emphasis on new phases, structures, shapes and complexity -Nanostructures involving molecular inorganic species such as nanoparticles of coordination compounds, molecular magnets, spin transition nanoparticles etc. or organic nano-objects, in particular for molecular electronics -Nanostructured materials such as nano-MOFs and nano-zeolites -Hetero-junctions between molecules and nano-objects, between different nano-objects & nanostructures or between nano-objects & nanostructures and surfaces -Methods of characterization specific of the nano size or adapted for the nano size such as X-ray and neutron scattering, light scattering, NMR, Raman, Plasmonics, near field microscopies, various TEM and SEM techniques, magnetic studies, etc .