小鼠早期发育过程中无活性 X 染色体的结构重塑

IF 3.7 3区医学 Q2 CHEMISTRY, MEDICINAL

Chemical Research in Toxicology Pub Date : 2024-09-27 DOI:10.1038/s41588-024-01936-y

Edda G. Schulz, Alexandra Martitz

引用次数: 0

摘要

哺乳动物的非活性 X 染色体显示出以大规模结构为主的不寻常折叠。一项研究发现，在体细胞中众所周知的Dxz4分隔的巨型结构之前，Xist基因座上有一个具有边界的巨型结构。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Structural remodeling of the inactive X chromosome during early mouse development

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Structural remodeling of the inactive X chromosome during early mouse development

The mammalian inactive X chromosome shows unusual folding dominated by large-scale structures. A study finds a megadomain structure with a boundary at the Xist locus, preceding the well-known Dxz4-separated megadomains in somatic cells.

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来源期刊

Chemical Research in Toxicology 医学-毒理学

CiteScore

7.90

自引率

7.30%

发文量

215

审稿时长

3.5 months

期刊介绍： Chemical Research in Toxicology publishes Articles, Rapid Reports, Chemical Profiles, Reviews, Perspectives, Letters to the Editor, and ToxWatch on a wide range of topics in Toxicology that inform a chemical and molecular understanding and capacity to predict biological outcomes on the basis of structures and processes. The overarching goal of activities reported in the Journal are to provide knowledge and innovative approaches needed to promote intelligent solutions for human safety and ecosystem preservation. The journal emphasizes insight concerning mechanisms of toxicity over phenomenological observations. It upholds rigorous chemical, physical and mathematical standards for characterization and application of modern techniques.