CuI 催化的吡咯并[2,1-a]异喹啉和其他富电子杂环戊烯的硒化反应

IF 3.3 2区化学 Q1 CHEMISTRY, ORGANIC

The Journal of Organic Chemistry Pub Date : 2024-09-26 DOI:10.1021/acs.joc.4c01462

Jing Zhou, Jia-Yi Han, Xin Yu, Liu Yang, Man Jiang, Yun-Meng Li, Hai-Lei Cui

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引用次数: 0

摘要

我们建立了一种在 mCPBA（间氯过氧苯甲酸）存在下，于室温对吡咯并[2,1-a]异喹啉衍生物进行温和的 CuI 催化硒化反应的方法。相应的有机硒化物很容易制备，产率为 53-92%。这一工艺还可扩展到吡咯、氮杂吲哚和吲哚的改性，以中等至良好的收率制备出所需的杂环硒化物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

CuI-Catalyzed Selenylation of Pyrrolo[2,1-a]isoquinolines and Other Electron-Rich Heteroarenes

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CuI-Catalyzed Selenylation of Pyrrolo[2,1-a]isoquinolines and Other Electron-Rich Heteroarenes

We have established a mild CuI-catalyzed selenylation of pyrrolo[2,1-a]isoquinoline derivatives in the presence of mCPBA (m-chloroperoxybenzoic acid) at ambient temperature. Corresponding organoselenides have been prepared readily in 53–92% yields. This process can also be expanded to the modification of pyrroles, azaindole, and indoles, delivering the desired heterocyclic selenides in moderate to good yields.

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来源期刊

The Journal of Organic Chemistry 化学-有机化学

CiteScore

6.20

自引率

11.10%

发文量

1467

审稿时长

2 months

期刊介绍： The Journal of Organic Chemistry welcomes original contributions of fundamental research in all branches of the theory and practice of organic chemistry. In selecting manuscripts for publication, the editors place emphasis on the quality and novelty of the work, as well as the breadth of interest to the organic chemistry community.