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引用次数: 0
摘要
在此,我们介绍了在 200% 电池中对富含电子的烯烃进行电化学溴化的研究。首先,我们研究了过量的支持电解质(Bu4NBr)对化学溴化的影响。事实证明,使用 >4.0 等量的 Bu4NBr 可大大提高 O 取代和 N 取代烯烃溴化过程的区域选择性。随后,根据这些见解对线性配对电解进行了优化,许多富电子烯烃都能以极佳的区域选择性实现高产率溴化。使用 O2 作为牺牲起始材料,结合 2- 乙基蒽醌作为催化剂,可增强 H2O2 在阴极的形成,从而使相当多实例的电流效率大于 150%。
Electrochemical Bromination of Arenes in a 200% Cell.
Herein, we describe the investigation of electrochemical bromination of electron-rich arenes in a 200% cell. For this application, at first, the influence of an excess of supporting electrolyte (Bu4NBr) on chemical bromination was investigated. The application of >4.0 equiv of Bu4NBr proved to enhance the regioselectivity of the bromination process for O- and N-substituted arenes considerably. The linear paired electrolysis was then optimized upon these insights, and a number of electron-rich arenes could be brominated in high yields with excellent regioselectivity. The use of O2 as a sacrificial starting material in combination with 2-ethylanthraquinone as a catalyst leads to the enhanced formation of H2O2 at the cathode, resulting in current efficiencies >150% for a considerable number of examples.
期刊介绍:
The Journal of Organic Chemistry welcomes original contributions of fundamental research in all branches of the theory and practice of organic chemistry. In selecting manuscripts for publication, the editors place emphasis on the quality and novelty of the work, as well as the breadth of interest to the organic chemistry community.