宿主生理决定正常组织和致癌组织的突变情况

IF 31.7 1区生物学 Q1 GENETICS & HEREDITY

Nature genetics Pub Date : 2024-09-26 DOI:10.1038/s41588-024-01922-4

Nadia Nasreddin, Owen J. Sansom

引用次数: 0

摘要

随着年龄的增长，组织学上正常的组织中会出现成片的突变克隆，从而导致体细胞突变。这些克隆的持续性、扩展性以及在生理和肿瘤发生中的作用尚不清楚。有关 Pik3caH1047R 突变食管克隆行为的新研究表明，宿主依赖性代谢特征是其扩张的基础。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Host physiology shapes the mutational landscape of normal and carcinogenic tissue

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Host physiology shapes the mutational landscape of normal and carcinogenic tissue

Somatic mutations accrue with age as patches of mutant clones arise in otherwise histologically normal tissue. The clones’ persistence, expansion and roles in physiology and tumorigenesis are unclear. New work on the behavior of Pik3caH1047R mutant esophageal clones shows that host-dependent metabolic features underpin their expansion.

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来源期刊

Nature genetics 生物-遗传学

CiteScore

43.00

自引率

2.60%

发文量

241

审稿时长

3 months

期刊介绍： Nature Genetics publishes the very highest quality research in genetics. It encompasses genetic and functional genomic studies on human and plant traits and on other model organisms. Current emphasis is on the genetic basis for common and complex diseases and on the functional mechanism, architecture and evolution of gene networks, studied by experimental perturbation. Integrative genetic topics comprise, but are not limited to: -Genes in the pathology of human disease -Molecular analysis of simple and complex genetic traits -Cancer genetics -Agricultural genomics -Developmental genetics -Regulatory variation in gene expression -Strategies and technologies for extracting function from genomic data -Pharmacological genomics -Genome evolution