与牙周炎和癌症相关的炎症指数。

IF 17.5 1区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE
Kay-Arne Walther,Sabine Gröger,Jonas Adrian Helmut Vogler,Bernd Wöstmann,Jörg Meyle
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引用次数: 0

摘要

炎症是一个复杂的生理过程,在许多甚至所有病理情况下都起着关键作用,包括感染性和炎症性疾病,如牙周炎和自身免疫性疾病。牙周炎中对牙周生物膜和组织破坏的炎症反应与炎症介质的释放有关。慢性炎症可促进癌症的发展。炎症介质的持续存在在这一过程中起着至关重要的作用。量化和监测与癌症相关的炎症严重程度至关重要。牙周炎的量化主要基于附着丧失和/或牙周袋探诊深度的严重程度和范围,以及探诊时的出血情况。近年来,研究开始调查与牙周疾病相关的炎症指数。迄今为止,关于血细胞计数、炎症指数和牙周炎之间关系的综述还寥寥无几。本综述全面概述了不同的全身炎症指数、其测量方法以及与牙周炎和癌症有关的临床应用。本综述概述了炎症的生理基础以及所述参数的潜在细胞和分子机制。牙周病学中常用的主要炎症指数包括中性粒细胞与淋巴细胞比值。血小板与淋巴细胞比值、血小板分布宽度、血小板crit、红细胞分布宽度、淋巴细胞与单核细胞比值、δ中性粒细胞指数和全身免疫炎症指数等炎症指数也在医院环境中使用,将对这些指数进行讨论。此外,还将介绍这些指标的临床作用和局限性、与全身性疾病的关系以及与牙周炎和治疗反应的关系。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Inflammation indices in association with periodontitis and cancer.
Inflammation is a complex physiological process that plays a pivotal role in many if not all pathological conditions, including infectious as well as inflammatory diseases, like periodontitis and autoimmune disorders. Inflammatory response to periodontal biofilms and tissue destruction in periodontitis is associated with the release of inflammatory mediators. Chronic inflammation can promote the development of cancer. Persistence of inflammatory mediators plays a crucial role in this process. Quantification and monitoring of the severity of inflammation in relation to cancer is essential. Periodontitis is mainly quantified based on the severity and extent of attachment loss and/or pocket probing depth, in addition with bleeding on probing. In recent years, studies started to investigate inflammation indices in association with periodontal diseases. To date, only few reviews have been published focusing on the relationship between blood cell count, inflammation indices, and periodontitis. This review presents a comprehensive overview of different systemic inflammation indices, their methods of measurement, and the clinical applications in relation to periodontitis and cancer. This review outlines the physiological basis of inflammation and the underlying cellular and molecular mechanisms of the parameters described. Key inflammation indices are commonly utilized in periodontology such as the neutrophil to lymphocyte ratio. Inflammation indices like the platelet to lymphocyte ratio, platelet distribution width, plateletcrit, red blood cell distribution width, lymphocyte to monocyte ratio, delta neutrophil index, and the systemic immune inflammation index are also used in hospital settings and will be discussed. The clinical roles and limitations, relationship to systemic diseases as well as their association to periodontitis and treatment response are described.
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来源期刊
Periodontology 2000
Periodontology 2000 医学-牙科与口腔外科
CiteScore
34.10
自引率
2.20%
发文量
62
审稿时长
>12 weeks
期刊介绍: Periodontology 2000 is a series of monographs designed for periodontists and general practitioners interested in periodontics. The editorial board selects significant topics and distinguished scientists and clinicians for each monograph. Serving as a valuable supplement to existing periodontal journals, three monographs are published annually, contributing specialized insights to the field.
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