用于生物医学应用的蛋白质水凝胶

IF 1.6 Q4 ENGINEERING, BIOMEDICAL
Xinyi Wang, Yue Hou, Xiong Lu, Chaoming Xie, Yanan Jiang
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引用次数: 0

摘要

水凝胶是一种高度亲水的三维聚合物网络,因其独特的物理化学特性而受到越来越多的关注,并被广泛应用于各个领域。与传统的合成聚合物水凝胶相比,天然聚合物水凝胶具有更高的生物相容性和生物可降解性。蛋白质是天然聚合物水凝胶的主要材料,具有许多可修饰的官能团。由此制成的水凝胶具有响应性和可调降解性,是一种极佳的生物材料。本文介绍了用于构建蛋白质水凝胶的七种常用原材料。在天然聚合物水凝胶与传统合成聚合物水凝胶的比较方面,作者进行了详细的分析和比较,强调了天然聚合物水凝胶在生物相容性和生物降解性方面的优势,并总结了它们的特点。作者还针对各种蛋白质水凝胶的局限性,列举了现有的强化交联策略,提出了克服蛋白质水凝胶应用局限性的新见解。此外,还讨论了蛋白质水凝胶在药物输送、生物传感、生物连接和组织工程方面的应用。最后,作者总结了蛋白质水凝胶当前面临的挑战,并展望了其未来的发展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Protein hydrogels for biomedical applications

Protein hydrogels for biomedical applications

Hydrogels, characterised as highly hydrophilic three-dimensional polymer networks, have gained increasing attention due to their unique physicochemical properties, finding applications in various fields. Natural polymer hydrogels exhibit higher biocompatibility and biodegradability compared to traditional synthetic polymer hydrogels. Proteins, being the principal materials of natural polymer hydrogels, bear numerous modifiable functional groups. The resultant hydrogel possesses responsiveness, adjustable degradability, and underway as an excellent biomaterial. Seven common raw materials used to construct protein hydrogels are introduced. In terms of comparing natural polymer hydrogels with traditional synthetic polymer hydrogels, the authors conduct a detailed analysis and comparison, highlighting the advantages of natural polymer hydrogels in terms of biocompatibility and biodegradability, and summarising their characteristics. The authors also address the limitations of various protein hydrogels and list existing strengthening cross-linking strategies, proposing new insights to overcome the application limits of protein hydrogels. Additionally, the applications of protein hydrogels in drug delivery, biosensing, bio-inks and tissue engineering are discussed. The authors conclude by summarising the current challenges faced by protein hydrogels and prospecting its future development.

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来源期刊
Biosurface and Biotribology
Biosurface and Biotribology Engineering-Mechanical Engineering
CiteScore
1.70
自引率
0.00%
发文量
27
审稿时长
11 weeks
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