硫代羰基引导的铱催化吲哚和吡咯与氢硅烷的 C-H 硅烷化反应

IF 4.4 2区化学 Q2 CHEMISTRY, APPLIED

Advanced Synthesis & Catalysis Pub Date : 2025-02-04 DOI:10.1002/adsc.202400903

Yi Cheng , Jingyi Zhan , Lei Wang , Houyun Teng , Li‐Wen Xu , Lei Yang

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引用次数: 0

摘要

本文介绍了通过 C(sp<sup>2</sup>)-H 键活化，以氢硅烷催化吲哚和吡咯与氢硅烷的无氢受体 C2 选择性 C-H 硅烷化反应，从而生成所需的硅烷化产物。在铱催化下，所开发的方案可使多种官能化吲哚与一氢硅烷发生 C-H 硅烷化反应。值得注意的是，这一过程是罕见的使用 <i>S</i>定向基团对 C-H 键进行硅烷化的过程。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Thiocarbonyl‐Directed Iridium‐Catalyzed C−H Silylation of Indoles and Pyrroles with Hydrosilanes

Herein, hydrogen‐acceptor‐free C2‐selective iridium‐catalyzed C−H silylation of indoles and pyrroles with hydrosilanes via C(sp²)−H bond activation to generate the desired silylated products is presented. The developed protocol allows for the C−H silylation of a wide range of functionalized indoles with monohydrosilanes under iridium catalysis. Significantly, this process represents a rare silylation of C−H bonds using S‐directing groups.

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来源期刊

Advanced Synthesis & Catalysis 化学-应用化学

CiteScore

9.40

自引率

7.40%

发文量

447

审稿时长

1.8 months

期刊介绍： Advanced Synthesis & Catalysis (ASC) is the leading primary journal in organic, organometallic, and applied chemistry. The high impact of ASC can be attributed to the unique focus of the journal, which publishes exciting new results from academic and industrial labs on efficient, practical, and environmentally friendly organic synthesis. While homogeneous, heterogeneous, organic, and enzyme catalysis are key technologies to achieve green synthesis, significant contributions to the same goal by synthesis design, reaction techniques, flow chemistry, and continuous processing, multiphase catalysis, green solvents, catalyst immobilization, and recycling, separation science, and process development are also featured in ASC. The Aims and Scope can be found in the Notice to Authors or on the first page of the table of contents in every issue.