用于 RNA 蛋白交联的光活化 mRNA 5′ Cap 类似物（科学进展 36/2024 号）

IF 14.3 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Advanced Science Pub Date : 2024-09-25 DOI:10.1002/advs.202470219

Marcin Warminski, Katarzyna Grab, Kacper Szczepanski, Tomasz Spiewla, Joanna Zuberek, Joanna Kowalska, Jacek Jemielity

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引用次数: 0

摘要

经化学修饰的信使核糖核酸（mRNA）已被证明是抗病毒疫苗的重要治疗平台。然而，要开发出更有效的疗法，就必须更全面地了解其翻译机制。封面图片描绘的是翻译起始因子 4E 与 mRNA 5′ 端帽结构的复合物，Marcin Warminski 及其合作者对其进行了修改，以创建新型分子工具，用于识别不同 mRNA 5′ 端变体的结合体。更多详情可参见文章编号 2400994。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Photoactivatable mRNA 5′ Cap Analogs for RNA-Protein Crosslinking (Adv. Sci. 36/2024)

查看原文本刊更多论文

Photoactivatable mRNA 5′ Cap Analogs for RNA-Protein Crosslinking (Adv. Sci. 36/2024)

mRNA Cap Photoaffinity Labeling Probes

Chemically modified messenger RNA (mRNA) has been demonstrated to be a valuable therapeutic platform for antiviral vaccines. However, a more comprehensive understanding of its translation mechanisms is essential for the development of more effective therapeutics. The cover image depicts a translation initiation factor 4E in complex with an mRNA 5′ cap structure, which was modified by Marcin Warminski and co-workers to create novel molecular tools for the identification of binders of different mRNA 5′-end variants. More details can be found in article number 2400994.

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来源期刊

Advanced Science CHEMISTRY, MULTIDISCIPLINARYNANOSCIENCE &-NANOSCIENCE & NANOTECHNOLOGY

CiteScore

18.90

自引率

2.60%

发文量

1602

审稿时长

1.9 months

期刊介绍： Advanced Science is a prestigious open access journal that focuses on interdisciplinary research in materials science, physics, chemistry, medical and life sciences, and engineering. The journal aims to promote cutting-edge research by employing a rigorous and impartial review process. It is committed to presenting research articles with the highest quality production standards, ensuring maximum accessibility of top scientific findings. With its vibrant and innovative publication platform, Advanced Science seeks to revolutionize the dissemination and organization of scientific knowledge.