夫妇配子冷冻卵母细胞所生子女的认知、情感、交流和运动发育。20 年的单中心经验

IF 2.1 4区医学 Q2 OBSTETRICS & GYNECOLOGY

European journal of obstetrics, gynecology, and reproductive biology Pub Date : 2024-09-19 DOI:10.1016/j.ejogrb.2024.09.029

Massimo Romano , Federico Cirillo , Miriam Comparini , Valentina Immediata , Andrea Busnelli , Emanuela Morenghi , Elena Albani , Paolo Emanuele Levi-Setti

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引用次数: 0

摘要

研究对象这是一项单中心人群研究，研究对象为2003年1月1日至2021年12月31日期间在Humanitas生育中心通过冷冻保存卵母细胞体外受精周期出生的所有儿童。主要结果包括各年龄段达到相关里程碑的儿童比例。在小于 6 岁的儿童中，如果有≥ 75% 的受试儿童表达了所测试的能力，则被视为达到了所研究的各年龄人口亚组的里程碑。结果共有 355 名符合纳入和排除标准的活产婴儿被纳入研究。结果表明，6 岁以下各年龄分组的儿童在问卷调查的所有里程碑中得分均≥ 75%。根据家长的判断，得分最低的里程碑包括同伴间互动（72.31%）和性与情感关系（63.08%）。同样，学龄儿童、青春期前儿童和青少年的情绪健康和社会参与也与同龄人一致。

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Cognitive, emotional, communicative, and motor development in children born from couple’s gametes cryopreserved oocytes. A 20 years single-center experience

Objective

To study if social and emotional, communicative, cognitive, motor development of children born from cryopreserved oocytes are comparable to general population.

Design

Survey study.

Exposure

This is a single-center population study, focusing on all children born from cycles of in vitro fertilization of cryopreserved oocytes at Humanitas Fertility Center from January 1st,2003, until December 31st, 2021.

Main outcome measures

General information about birth history were collected from all parents. Then, screening for developmental delay was performed by administration of a questionnaire, edited according to milestones set for age by the Center for Disease Control and Prevention.

Primary outcomes included the percentage of children, for each age range, that reached related milestones. In children younger than 6 years of age, milestones were considered to be reached by each age-based population subgroup studied when ≥ 75 % of included children expressed the tested competences.

Results

A total of 355 live births fulfilled the inclusion and exclusion criteria and were included in the study. Results showed that each age-based population subgroup, younger than 6 years of age, scored ≥ 75 % in all the milestones included in the questionnaire.

In preadolescents and adolescents, it was noted a decrease in unstructured in-person socializing. Indeed, milestones that scored the lowest values, based on parents’ judgement, included tasks concerning peer-to-peer interaction (72.31%) and sexuality and sentimental relationships (63.08%).

Conclusions

Results indicated that the achievement of emotional, communicative, cognitive, and motor milestones in infants, toddlers, and preschoolers was comparable to the general pediatric population. Similarly, emotional wellbeing and social engagement in school-aged children, preadolescents, and adolescents were in line with their peers.

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来源期刊

European journal of obstetrics, gynecology, and reproductive biology 医学-妇产科学

CiteScore

4.60

自引率

3.80%

发文量

898

审稿时长

8.3 weeks

期刊介绍： The European Journal of Obstetrics & Gynecology and Reproductive Biology is the leading general clinical journal covering the continent. It publishes peer reviewed original research articles, as well as a wide range of news, book reviews, biographical, historical and educational articles and a lively correspondence section. Fields covered include obstetrics, prenatal diagnosis, maternal-fetal medicine, perinatology, general gynecology, gynecologic oncology, uro-gynecology, reproductive medicine, infertility, reproductive endocrinology, sexual medicine and reproductive ethics. The European Journal of Obstetrics & Gynecology and Reproductive Biology provides a forum for scientific and clinical professional communication in obstetrics and gynecology throughout Europe and the world.