非最佳温度改变了中国PM2.5及其成分与慢性肾病住院之间的关系

Q1 Social Sciences
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引用次数: 0

摘要

关于暴露于细颗粒物(PM2.5)及其成分是否与慢性肾病(CKD)住院风险升高有关的流行病学证据仍然不足。此外,环境温度对 PM2.5 的影响是否有潜在的调节作用,目前仍不清楚。在本研究中,我们收集了中国 260 个城市的 2,259,240 份慢性肾脏病住院记录样本。通过时空分层病例交叉设计确定了空气污染物与慢性肾脏病住院之间的关联。我们进一步评估了 PM2.5 及其成分在三个温度分层(即最低温度(第 25 位)、中等温度(第 25-75 位)和最高温度(第 75 位))中的影响。研究结果表明,慢性肾脏病住院风险与 PM2.5、黑碳(BC)、硫酸盐(SO42-)、硝酸盐(NO3-)、铵(NH4+)和有机物(OM)暴露之间存在明显的单调关系。例如,随着 PM2.5 的四分位数间增量(29.47 μg/m3),滞后 0-4 天的相对风险(RR)为 1.016(95 % 置信区间 [CI]:1.012-1.019)。较高的环境温度明显加剧了PM2.5及其成分对慢性肾脏病住院率的估计影响,而在较低温度下,SO42-和NO3-的相关性也明显增强。不同病因的慢性肾脏病和不同的地理区域,非最佳温度的调节作用也不尽相同。这项研究为气候变化和空气污染对肾脏健康的共同影响提供了见解。这些发现凸显了针对高浓度PM2.5和非最佳温度对易感人群采取保护措施的必要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Non-optimum temperatures modified the associations between PM2.5 and its components and hospitalizations for chronic kidney disease in China
Epidemiological evidence concerning whether exposure to fine particulate matter (PM2.5) and its components was linked to an elevated risk of hospitalizations for chronic kidney disease (CKD) remains insufficient. Moreover, it remains unclear whether ambient temperatures have potential modification effects on PM2.5's impacts. In the current study, we collected a nationwide sample of 2,259,240 hospitalization records for CKD in 260 Chinese cities. The associations between air pollutants and CKD hospitalizations were determined by the space-time-stratified case-crossover design. We further assessed the effects of PM2.5 and its components in three temperature strata [i.e., lowest (<25th), medium (25–75th), and highest (>75th)]. The findings demonstrated the significant and monotonic associations between risk of CKD hospitalizations and exposure to PM2.5, black carbon (BC), sulfate (SO42−), nitrate (NO3), ammonium (NH4+), and organic matter (OM). For instance, along with an interquartile range increment in PM2.5 (29.47 μg/m3), the relative risks (RR) were 1.016 (95 % confidence interval [CI]:1.012–1.019) at lag 0–4 days. Higher ambient temperature significantly exacerbated the estimated impact of PM2.5 and its components on CKD hospitalizations, while significantly stronger associations were also observed at lower temperature for SO42− and NO3. The modification effects of non-optimum temperatures varied among different etiologies of CKD and geographic regions. This study provides insights into the joint kidney health effects of climate change and air pollution. These findings highlight the necessity of protection measures against high concentration of PM2.5 and non-optimum temperatures for the vulnerable populations.
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来源期刊
Global Transitions
Global Transitions Social Sciences-Development
CiteScore
18.90
自引率
0.00%
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1
审稿时长
20 weeks
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