Isolation of four new phenolic compounds from the fungus Talaromyces cellulolyticus

Four new phenolic compounds talarocelic A–D (1–4), together with four known compounds (5–8) were isolated from the fungus Talaromyces cellulolyticus CBS136886. Their chemical structures were elucidated through extensive spectroscopic data analysis such as HR-ESI-MS, UV, IR, and 1D- and 2D-NMR. Biological assay results revealed that compound 6 displayed potent protein tyrosine phosphatase 1B and α-glucosidase inhibitory activities with inhibition rates of 91.7 % and 59.6 %, respectively, at 10 μM. In addition, compound 6 showed moderate anti-inflammatory activity with 56.4 % inhibition at 10 μM and anti-bacterial activity against Staphylococcus aureus with a minimum inhibitory concentration of 12.5 μg/mL. This work not only reveals that T. cellulolyticus is rich in phenolic compounds but also provides access to diverse bioactive lead compounds for drug discovery.