顺铂的替代品 - 引入铑类似物

IF 3.2 4区 化学 Q2 CHEMISTRY, MULTIDISCIPLINARY
Arup Mandal
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引用次数: 0

摘要

自 1978 年发现并批准使用顺式铂以来,使用过渡金属络合物作为抗癌剂的情况最为普遍。人们发现了不同的铂络合物类似物,并对其进行了进一步研究,以寻求最大的靶向效率。但人们很快意识到,铂络合物有许多副作用,如抗药性、神经毒性等,因此无法达到最终预期。因此,科学家们开始研究其他有效的替代品,以克服铂类似物的局限性,并显示出诱导肿瘤细胞死亡的能力。在这篇综述中,我们试图讨论铑类似物如何成为比顺铂更好的抗癌剂替代品。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Alternative of cisplatin - Introduction of rhodium analogues
The use of transition metal complexes as anti-cancer agents became most practiced since the discovery and approval of cis-platin in 1978. Different analogues of platinum complexes were discovered and further investigated to find maximum efficiency on the target. But it was soon realized, the Pt-complexes had numerous side effects like resistance, neurotoxicity, etc. by which they couldn't reach to their final expectation. Hence, scientists researched other efficient alternatives, which can defeat the limitations of platinum analogues and shows capability in induced tumour cell death. In this review, we attempted to discuss how rhodium analogues can be a better alternative than cis-platin as an anti-cancer agent.
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来源期刊
CiteScore
3.50
自引率
7.70%
发文量
492
审稿时长
3-8 weeks
期刊介绍: The Journal of the Indian Chemical Society publishes original, fundamental, theorical, experimental research work of highest quality in all areas of chemistry, biochemistry, medicinal chemistry, electrochemistry, agrochemistry, chemical engineering and technology, food chemistry, environmental chemistry, etc.
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