脂多糖类内毒素与视网膜神经变性的关系:Alienor研究

IF 3.2 Q1 OPHTHALMOLOGY
Petra P. Larsen MD , Catherine Féart PhD , Jean-Paul Pais de Barros PhD , Laure Gayraud MSc , Marie-Noëlle Delyfer MD, PhD , Jean-François Korobelnik MD , Cédric Schweitzer MD, PhD , Cécile Delcourt PhD
{"title":"脂多糖类内毒素与视网膜神经变性的关系:Alienor研究","authors":"Petra P. Larsen MD ,&nbsp;Catherine Féart PhD ,&nbsp;Jean-Paul Pais de Barros PhD ,&nbsp;Laure Gayraud MSc ,&nbsp;Marie-Noëlle Delyfer MD, PhD ,&nbsp;Jean-François Korobelnik MD ,&nbsp;Cédric Schweitzer MD, PhD ,&nbsp;Cécile Delcourt PhD","doi":"10.1016/j.xops.2024.100610","DOIUrl":null,"url":null,"abstract":"<div><h3>Purpose</h3><div>Lipopolysaccharide (LPS)-type endotoxins are naturally found in the gut microbiota and there is emerging evidence linking gut microbiota and neuroinflammation leading to retinal neurodegeneration. Thinning of the retinal nerve fiber layer (RNFL) is a biomarker of retinal neurodegeneration, and a hallmark of glaucoma, the second leading cause of blindness worldwide. We assessed the association of a blood biomarker of LPS with peripapillary RNFL thickness (RNFLT) and its longitudinal evolution up to 11 years.</div></div><div><h3>Design</h3><div>The Alienor study is a single center prospective population-based cohort study.</div></div><div><h3>Subjects</h3><div>The studied sample of this study includes 1062 eyes of 548 participants receiving ≥1 gradable RNFL measurement.</div></div><div><h3>Methods</h3><div>Plasma esterified 3-hydroxy fatty acids (3-OH FAs) were measured as a proxy of LPS burden. Retinal nerve fiber layer thickness was acquired using spectral-domain OCT imaging every 2 years from 2009 to 2020 (up to 5 visits).</div></div><div><h3>Main Outcome Measures</h3><div>Associations of plasma esterified 3-OH FAs with RNFLT were assessed using linear mixed models.</div></div><div><h3>Results</h3><div>Mean age of the included 548 participants was 82.4 ± 4.3 years and 62.6% were women. Higher plasma esterified 3-OH FAs was significantly associated with thinner RNFLT at baseline (coefficient beta = −1.42 microns for 1 standard deviation-increase in 3-OH FAs, 95% confidence interval [−2.56; −0.28], <em>P</em> = 0.02). This association remained stable after multivariate adjustment for potential confounders. No statistically significant association was found between 3-OH FAs and longitudinal RNFLT change.</div></div><div><h3>Conclusions</h3><div>Higher plasma esterified 3-OH FAs were associated with thinner RNFLT at baseline, indicating an involvement of LPS in the early processes of optic nerve neurodegeneration and highlighting the potential importance of the human microbiota in preserving retinal health.</div></div><div><h3>Financial Disclosure(s)</h3><div>Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.</div></div>","PeriodicalId":74363,"journal":{"name":"Ophthalmology science","volume":null,"pages":null},"PeriodicalIF":3.2000,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666914524001465/pdfft?md5=d87b134146a791f80cb8b2ca7c30456e&pid=1-s2.0-S2666914524001465-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Association of Lipopolysaccharide-Type Endotoxins with Retinal Neurodegeneration: The Alienor Study\",\"authors\":\"Petra P. Larsen MD ,&nbsp;Catherine Féart PhD ,&nbsp;Jean-Paul Pais de Barros PhD ,&nbsp;Laure Gayraud MSc ,&nbsp;Marie-Noëlle Delyfer MD, PhD ,&nbsp;Jean-François Korobelnik MD ,&nbsp;Cédric Schweitzer MD, PhD ,&nbsp;Cécile Delcourt PhD\",\"doi\":\"10.1016/j.xops.2024.100610\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Purpose</h3><div>Lipopolysaccharide (LPS)-type endotoxins are naturally found in the gut microbiota and there is emerging evidence linking gut microbiota and neuroinflammation leading to retinal neurodegeneration. Thinning of the retinal nerve fiber layer (RNFL) is a biomarker of retinal neurodegeneration, and a hallmark of glaucoma, the second leading cause of blindness worldwide. We assessed the association of a blood biomarker of LPS with peripapillary RNFL thickness (RNFLT) and its longitudinal evolution up to 11 years.</div></div><div><h3>Design</h3><div>The Alienor study is a single center prospective population-based cohort study.</div></div><div><h3>Subjects</h3><div>The studied sample of this study includes 1062 eyes of 548 participants receiving ≥1 gradable RNFL measurement.</div></div><div><h3>Methods</h3><div>Plasma esterified 3-hydroxy fatty acids (3-OH FAs) were measured as a proxy of LPS burden. Retinal nerve fiber layer thickness was acquired using spectral-domain OCT imaging every 2 years from 2009 to 2020 (up to 5 visits).</div></div><div><h3>Main Outcome Measures</h3><div>Associations of plasma esterified 3-OH FAs with RNFLT were assessed using linear mixed models.</div></div><div><h3>Results</h3><div>Mean age of the included 548 participants was 82.4 ± 4.3 years and 62.6% were women. Higher plasma esterified 3-OH FAs was significantly associated with thinner RNFLT at baseline (coefficient beta = −1.42 microns for 1 standard deviation-increase in 3-OH FAs, 95% confidence interval [−2.56; −0.28], <em>P</em> = 0.02). This association remained stable after multivariate adjustment for potential confounders. No statistically significant association was found between 3-OH FAs and longitudinal RNFLT change.</div></div><div><h3>Conclusions</h3><div>Higher plasma esterified 3-OH FAs were associated with thinner RNFLT at baseline, indicating an involvement of LPS in the early processes of optic nerve neurodegeneration and highlighting the potential importance of the human microbiota in preserving retinal health.</div></div><div><h3>Financial Disclosure(s)</h3><div>Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.</div></div>\",\"PeriodicalId\":74363,\"journal\":{\"name\":\"Ophthalmology science\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":3.2000,\"publicationDate\":\"2024-08-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S2666914524001465/pdfft?md5=d87b134146a791f80cb8b2ca7c30456e&pid=1-s2.0-S2666914524001465-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Ophthalmology science\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2666914524001465\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"OPHTHALMOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Ophthalmology science","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2666914524001465","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"OPHTHALMOLOGY","Score":null,"Total":0}
引用次数: 0

摘要

目的 脂多糖(LPS)型内毒素天然存在于肠道微生物群中,有新证据表明肠道微生物群与导致视网膜神经变性的神经炎症有关。视网膜神经纤维层(RNFL)变薄是视网膜神经变性的生物标志物,也是全球第二大致盲原因青光眼的标志物。我们评估了血液中 LPS 的生物标志物与毛细血管周围 RNFL 厚度(RNFLT)的关联性及其长达 11 年的纵向演变情况。主要结果测量采用线性混合模型评估血浆酯化3-OH脂肪酸与RNFLT的相关性。结果548名参与者的平均年龄为82.4 ± 4.3岁,62.6%为女性。较高的血浆酯化 3-OH FAs 与基线较薄的 RNFLT 显著相关(3-OH FAs 每增加 1 个标准差,贝塔系数 = -1.42 微米,95% 置信区间 [-2.56; -0.28],P = 0.02)。在对潜在的混杂因素进行多变量调整后,这种关联仍然保持稳定。结论较高的血浆酯化3-OH FAs与基线时较薄的RNFLT相关,表明LPS参与了视神经变性的早期过程,并强调了人类微生物群在保护视网膜健康方面的潜在重要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Association of Lipopolysaccharide-Type Endotoxins with Retinal Neurodegeneration: The Alienor Study

Purpose

Lipopolysaccharide (LPS)-type endotoxins are naturally found in the gut microbiota and there is emerging evidence linking gut microbiota and neuroinflammation leading to retinal neurodegeneration. Thinning of the retinal nerve fiber layer (RNFL) is a biomarker of retinal neurodegeneration, and a hallmark of glaucoma, the second leading cause of blindness worldwide. We assessed the association of a blood biomarker of LPS with peripapillary RNFL thickness (RNFLT) and its longitudinal evolution up to 11 years.

Design

The Alienor study is a single center prospective population-based cohort study.

Subjects

The studied sample of this study includes 1062 eyes of 548 participants receiving ≥1 gradable RNFL measurement.

Methods

Plasma esterified 3-hydroxy fatty acids (3-OH FAs) were measured as a proxy of LPS burden. Retinal nerve fiber layer thickness was acquired using spectral-domain OCT imaging every 2 years from 2009 to 2020 (up to 5 visits).

Main Outcome Measures

Associations of plasma esterified 3-OH FAs with RNFLT were assessed using linear mixed models.

Results

Mean age of the included 548 participants was 82.4 ± 4.3 years and 62.6% were women. Higher plasma esterified 3-OH FAs was significantly associated with thinner RNFLT at baseline (coefficient beta = −1.42 microns for 1 standard deviation-increase in 3-OH FAs, 95% confidence interval [−2.56; −0.28], P = 0.02). This association remained stable after multivariate adjustment for potential confounders. No statistically significant association was found between 3-OH FAs and longitudinal RNFLT change.

Conclusions

Higher plasma esterified 3-OH FAs were associated with thinner RNFLT at baseline, indicating an involvement of LPS in the early processes of optic nerve neurodegeneration and highlighting the potential importance of the human microbiota in preserving retinal health.

Financial Disclosure(s)

Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Ophthalmology science
Ophthalmology science Ophthalmology
CiteScore
3.40
自引率
0.00%
发文量
0
审稿时长
89 days
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信