通过动态动力学解析进行伯醇的不对称胺化:手性苯并吗啉的对映转化途径

IF 9.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Yaru Gao, Guorong Hong, Lei Zhang, Ke-Yin Ye, Jiajia Cheng, Bin-Miao Yang, Yu Zhao
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引用次数: 0

摘要

我们在此介绍一种催化对映体转化的醇胺化反应,用于高效获得手性 C2-和 C3-取代的苯并吗啉。不同取代方式的外消旋氨基醇底物很容易从一种共同的前体中获得,并能以高度原子和步进经济的方式转化为对映体丰富的杂环。特别是,在铱/铁协同催化下,通过动态动力学解析,实现了外消旋伯醇前所未有的不对称胺化,从而得到了难以通过其他途径获得的高对映体 C2 取代的苯并吗啉。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Asymmetric Amination of Primary Alcohols via Dynamic Kinetic Resolution: Enantioconvergent Access to Chiral Benzomorpholines

We present here a catalytic enantioconvergent amination of alcohols for efficient access to chiral C2- and C3-substituted benzomorpholines. The racemic amino alcohol substrates of different substitution patterns, which are readily available from a common precursor, can be converted to the enantioenriched heterocycles in a highly atom- and step-economical fashion. In particular, an unprecedented asymmetric amination of racemic primary alcohols via dynamic kinetic resolution is achieved under cooperative iridium/iron catalysis, resulting in highly enantioenriched C2-substituted benzomorpholines that are difficult to access otherwise.

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来源期刊
CCS Chemistry
CCS Chemistry Chemistry-General Chemistry
CiteScore
13.60
自引率
13.40%
发文量
475
审稿时长
10 weeks
期刊介绍: CCS Chemistry, the flagship publication of the Chinese Chemical Society, stands as a leading international chemistry journal based in China. With a commitment to global outreach in both contributions and readership, the journal operates on a fully Open Access model, eliminating subscription fees for contributing authors. Issued monthly, all articles are published online promptly upon reaching final publishable form. Additionally, authors have the option to expedite the posting process through Immediate Online Accepted Article posting, making a PDF of their accepted article available online upon journal acceptance.
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