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正交氧化还原控制

IF 12.9 1区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Nature chemical biology Pub Date : 2024-09-24 DOI:10.1038/s41589-024-01728-9
Lena M. Hümmler, Steffen N. Lindner
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引用次数: 0

摘要

整合新的正交氧化还原辅助因子为控制反应平衡提供了机会。由于它不会干扰细胞的氧化还原平衡，因此这种方法能够精确调整代谢途径，优化微生物的生物生产，而不受典型氧化还原平衡的影响。
本文章由计算机程序翻译，如有差异，请以英文原文为准。

Orthogonal redox control

Orthogonal redox control

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Orthogonal redox control
The integration of a new orthogonal redox cofactor opens opportunities for controlling reaction equilibria. Because it does not interfere with cellular redox homeostasis, this approach enables the precise tuning of metabolic pathways and the optimization of microbial bioproduction, independently of canonical redox balancing.
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来源期刊
Nature chemical biology
Nature chemical biology 生物-生化与分子生物学
CiteScore
23.90
自引率
1.40%
发文量
238
审稿时长
12 months
期刊介绍： Nature Chemical Biology stands as an esteemed international monthly journal, offering a prominent platform for the chemical biology community to showcase top-tier original research and commentary. Operating at the crossroads of chemistry, biology, and related disciplines, chemical biology utilizes scientific ideas and approaches to comprehend and manipulate biological systems with molecular precision. The journal embraces contributions from the growing community of chemical biologists, encompassing insights from chemists applying principles and tools to biological inquiries and biologists striving to comprehend and control molecular-level biological processes. We prioritize studies unveiling significant conceptual or practical advancements in areas where chemistry and biology intersect, emphasizing basic research, especially those reporting novel chemical or biological tools and offering profound molecular-level insights into underlying biological mechanisms. Nature Chemical Biology also welcomes manuscripts describing applied molecular studies at the chemistry-biology interface due to the broad utility of chemical biology approaches in manipulating or engineering biological systems. Irrespective of scientific focus, we actively seek submissions that creatively blend chemistry and biology, particularly those providing substantial conceptual or methodological breakthroughs with the potential to open innovative research avenues. The journal maintains a robust and impartial review process, emphasizing thorough chemical and biological characterization.
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