吡唑嘧啶酮类支架的西地那非及其衍生物的合成

IF 1.7 4区化学

Bulletin of the Korean Chemical Society Pub Date : 2024-08-27 DOI:10.1002/bkcs.12893

Seung Su Lee, Chang Ho Oh

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引用次数: 0

摘要

吡唑环结构被广泛认为是现代有机合成工具箱中的药效源和强化剂，因此需要采用合成策略来生成其衍生物。尤其是吡唑嘧啶酮类化合物，是合成西地那非和洛地那非等 5 型磷酸二酯酶（PDE5）的关键部分。在此，我们报告了一种利用易得材料合成西地那非及其衍生物的简单而有效的方法。

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Synthesis of sildenafil and its derivatives bearing pyrazolo-pyrimidinones scaffold

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Synthesis of sildenafil and its derivatives bearing pyrazolo-pyrimidinones scaffold

The pyrazole ring structure is extensively spotted as a pharmacophore and fortify-cation of the modern organic synthesis toolbox, which demands synthetic tactics to generate its derivatives. Especially, pyrazolo-pyrimidinones are crucial part to synthesize phosphodiesterase type 5 (PDE5) such as sildenafil and lodenafil. Herein, we report a simple and efficient route for Sildenafil and derivatives from easily available materials.

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来源期刊

Bulletin of the Korean Chemical Society Chemistry-General Chemistry

自引率

23.50%

发文量

182

期刊介绍： The Bulletin of the Korean Chemical Society is an official research journal of the Korean Chemical Society. It was founded in 1980 and reaches out to the chemical community worldwide. It is strictly peer-reviewed and welcomes Accounts, Communications, Articles, and Notes written in English. The scope of the journal covers all major areas of chemistry: analytical chemistry, electrochemistry, industrial chemistry, inorganic chemistry, life-science chemistry, macromolecular chemistry, organic synthesis, non-synthetic organic chemistry, physical chemistry, and materials chemistry.