通过 AAV9 介导的 shRNA 敲除人类内源性逆转录病毒-K (HERV-K) env 可减轻转基因小鼠的肌萎缩性脊髓侧索硬化症 (ALS) 症状

{"title":"通过 AAV9 介导的 shRNA 敲除人类内源性逆转录病毒-K (HERV-K) env 可减轻转基因小鼠的肌萎缩性脊髓侧索硬化症 (ALS) 症状","authors":"Myoung-Hwa Lee Ph.D., Wenxue Li Ph.D., Kevon Sampson M.A., Melina Jones Ph.D., Joseph Steiner Ph.D., Avindra Nath M.D.","doi":"10.1016/j.neurot.2024.e00412","DOIUrl":null,"url":null,"abstract":"","PeriodicalId":5,"journal":{"name":"ACS Applied Materials & Interfaces","volume":null,"pages":null},"PeriodicalIF":8.3000,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1878747924000989/pdfft?md5=3e0b77b08421151d7a0d0eff129b7cc9&pid=1-s2.0-S1878747924000989-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Human Endogenous Retrovirus-K (HERV-K) env Knockdown by AAV9-mediated shRNA Attenuates Amyotrophic Lateral Sclerosis (ALS)-like Symptoms in Transgenic Mice\",\"authors\":\"Myoung-Hwa Lee Ph.D., Wenxue Li Ph.D., Kevon Sampson M.A., Melina Jones Ph.D., Joseph Steiner Ph.D., Avindra Nath M.D.\",\"doi\":\"10.1016/j.neurot.2024.e00412\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"\",\"PeriodicalId\":5,\"journal\":{\"name\":\"ACS Applied Materials & Interfaces\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":8.3000,\"publicationDate\":\"2024-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S1878747924000989/pdfft?md5=3e0b77b08421151d7a0d0eff129b7cc9&pid=1-s2.0-S1878747924000989-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"ACS Applied Materials & Interfaces\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1878747924000989\",\"RegionNum\":2,\"RegionCategory\":\"材料科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"MATERIALS SCIENCE, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Applied Materials & Interfaces","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1878747924000989","RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MATERIALS SCIENCE, MULTIDISCIPLINARY","Score":null,"Total":0}